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UnknownMacimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency.
Not available
S-EPMC4207947 | biostudies-literature
TranscriptomicsGenome Rearrangements and Pervasive Meiotic Drive Cause Hybrid Infertility in Fission Yeast
Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Uncovering the mechanisms of hybrid sterilitynot only provides insight into the origins of species but also potentially revealsnovel causes of intra-species infertility.Here we i...
ORGANISM(S): Schizosaccharomyces kambucha 
2014-05-15 | E-GEOD-57039 | biostudies-arrayexpress
ModelsLiu2023 - Acinetobacter baumannii growth inhibition prediction with Deep Learning
This model is a Chemprop neural network trained with a growth inhibition dataset. Authors screened ~7,500 molecules for those that inhibited the growth of A. baumannii in vitro. They discovered abaucin, an antibacterial compound with narrow-spectrum activity against A. baumannii. Model Type: Predic...
2024-05-28 | MODEL2405080001 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
ProteomicsProximal proteomics connects NRF2 suppression to ZNF746/PARIS-driven oxidative stress and apoptosis in Parkinson’s disease
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor activates cytoprotective and metabolic gene expression in response to various electrophilic stressors. In disease, constitutive NRF2 activity promotes cancer progression while decreased NRF2 function contributes to neurodege...
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD043248 | Pride
Znf746 Nrf2 Prm Parkinson's disease Paris Oxidative stress 
TranscriptomicsTranscription profiling of human papillary renal cell carcinoma to identify molecular PRCC subclasses with morphologic correlation
BACKGROUND: Despite the moderate incidence of papillary renal cell carcinoma; (PRCC), there is a disproportionately limited understanding of its underlying genetic programs. There is no effective therapy for metastatic PRCC, and patients are often excluded from kidney cancer trials. A morphological ...
ORGANISM(S): Homo sapiens 
2007-10-20 | E-GEOD-2748 | biostudies-arrayexpress
GenomicsCombinatorial transcription factor binding evolution in five placental mammals
Zoo-ChIP: Functional analysis of experimentally determined combinatorial transcription factor binding in multiple mammalian species
ORGANISM(S): Rattus norvegicus 
2014-09-27 | E-MTAB-1509 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hearts from wild type and thyroid hormone receptor beta-mutant mice (d337T TRb) treated with or without PPARalpha activator to study the molecular effect of thyroid hormone receptor on PPARalpha activation.
In this study we used the d337T TRb transgenic mouse that has been created to reproduce the human genetic disease known as resistance to thyroid hormone (RTH) as a model to determine if the d337T TRb mutation would have an effect on PPARa activation. A single amino acid deletion (d337T) abrogates ...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-3067 | biostudies-arrayexpress
ProteomicsProximal proteomics connects NRF2 suppression to ZNF746/PARIS-driven oxidative stress and apoptosis in Parkinson’s disease
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor activates cytoprotective and metabolic gene expression in response to various electrophilic stressors. In disease, constitutive NRF2 activity promotes cancer progression while decreased NRF2 function contributes to neurodege...
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD043182 | Pride
Znf746 Proximity proteomics Mafg Nrf2 Nrf3 Nrf1 Parkinson's disease Oxidative stress 
TranscriptomicsRgg-dependent transcriptional regulation in Streptococcus pyogenes strains MGAS5005 and CS101
Rgg-dependent transcriptional regulation in Streptococcus pyogenes strains MGAS5005 and CS101 was analyzed during post-exponential phase of growth Keywords: strain comparion, post-exponential growth, rgg mutant Microarray analysis was performed using RNA samples isolated from wild-type MGAS5005 and ...
ORGANISM(S): Streptococcus pyogenes 
2010-05-26 | E-GEOD-7341 | biostudies-arrayexpress
TranscriptomicsRgg-dependent transcriptional regulation in SF370 Streptococcus pyogenes strain
Rgg-dependent transcriptional regulation in SF370 Streptococcus pyogenes strain was analyzed during post-exponential phase of growth Keywords: rgg mutant Microarray analysis was performed using RNA samples isolated from both wild-type SF370 and SF370 rgg mutant strains during post-exponential phase ...
ORGANISM(S): Streptococcus pyogenes 
2010-05-26 | E-GEOD-7335 | biostudies-arrayexpress
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