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ProteomicsProximal proteomics connects NRF2 suppression to ZNF746/PARIS-driven oxidative stress and apoptosis in Parkinson’s disease
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor activates cytoprotective and metabolic gene expression in response to various electrophilic stressors. In disease, constitutive NRF2 activity promotes cancer progression while decreased NRF2 function contributes to neurodege...
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD043182 | Pride
Znf746 Proximity proteomics Mafg Nrf2 Nrf3 Nrf1 Parkinson's disease Oxidative stress 
TranscriptomicsHCT116 (CRC): control siRNA vs. ZNF746 siRNA Transfected
Transcriptional profiling of HCT116 cells compared to untreated control with HCT116 cells transfected with ZNF746 siRNA plasmid. Goal was to determine the effects of ZNF746 gene transfection on CRC progression. Two-condition experiment, HCT116 vs. ZNF746 siRNA.
ORGANISM(S): Homo sapiens 
2019-12-01 | GSE90832 | GEO
ProteomicsProximal proteomics connects NRF2 suppression to ZNF746/PARIS-driven oxidative stress and apoptosis in Parkinson’s disease
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor activates cytoprotective and metabolic gene expression in response to various electrophilic stressors. In disease, constitutive NRF2 activity promotes cancer progression while decreased NRF2 function contributes to neurodege...
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD043248 | Pride
Znf746 Nrf2 Prm Parkinson's disease Paris Oxidative stress 
GenomicsHomo sapiens
HCT116 (CRC): control siRNA vs. ZNF746 siRNA Transfected
PRJNA356271 | ENA
UnknownProximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2.
Not available
S-EPMC10760916 | biostudies-literature
UnknownPARIS/ZNF746 DNA-binding domain deficiency promotes adipose tissue hyperplasia and hepatic lipid accumulation.
Not available
S-EPMC12528463 | biostudies-literature
UnknownAcetylcytidine modification of DDX41 and ZNF746 by N-acetyltransferase 10 contributes to chemoresistance of melanoma.
Not available
S-EPMC11377236 | biostudies-literature
UnknownDUF3669, a "domain of unknown function" within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression.
Not available
S-EPMC6923878 | biostudies-literature
UnknownZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts.
Not available
S-EPMC7217926 | biostudies-literature
UnknownObesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis.
Not available
S-EPMC10752882 | biostudies-literature
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