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ProteomicsNovel protein interaction network of human calcitonin receptor-like receptor revealed by label-free quantitative proteomics
Background : The G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) is implicated in cardiovascular and skin diseases, migraine and cancer. Beyond its agonists, receptor activity-modifying proteins and receptor component protein, interacting partners of this GPCR (‘CLR interac...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD032156 | Pride
Skin. Endothelial cell Human Lymphatic Proteome 
ProteomicsIn-vitro Co-immunoprecipitation Mass Spectrometry of LUH and AP1 from Arabidopsis
This dataset contains quantitative co-immunoprecipitation mass spectrometry (Co-IP-MS) data generated to investigate direct interactions between the Arabidopsis co-regulator LUH and the MADS-domain transcription factor AP1. LUH wild type and domain variants (LUH_W, LUH_QW, LUH_LQ) were co-expressed ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Triticum aestivum (Wheat) 
2025-11-25 | PXD068765 | Pride
Arabidopsis Ap1 Luh Co-ip-ms 
ProteomicsFLEXIQuant-LF: Robust Regression to quantify protein modification extent in label-free proteomics data
Improvements in LC-MS/MS methods and technology have enabled the identification of thousands of modified peptides in a single experiment. However, protein regulation by post-translational modifications (PTMs) is not binary, making methods to quantify the modification extent crucial to fully understa...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD018411 | Pride
Dia Mass spectrometry Modification stochiometry Peptide modification Software Ptm quantification Ptm identification Open source Label-free quantification Dda 
UnknownAnalysis of Human Nuclear Protein Complexes by Quantitative Mass Spectrometry Profiling.
Not available
S-EPMC6387628 | biostudies-literature
ProteomicsCharacterization of novel human cystatin B salivary interactome in Alzheimer’s disease and healthy subjects.
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the elderly, characterized by the accumulation in the brain of misfolded proteins, inflammation, and oxidative damage leading to neuronal cell death. The necessity of searching for new non-invasive biomarkers in tissues or b...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD030679 | Pride
Coip Proteomics Alzheimer Cystatinb Lc-msms Interactome 
ProteomicsKLF5 co-immunoprecipitation mass spectrometry
Lineage plasticity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) and contributes to tumor heterogeneity and therapeutic resistance. Here, we identify KLF5 as a dynamic master regulator of epithelial lineage identity in PDAC, with dichotomous roles in promoting either classical or basal-li...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD066112 | Pride
Klf5 co-ip pdac 
ProteomicsZC3H11A interacts with PABPN1 and alters polyadenylation of viral transcripts
Nuclear mRNA metabolism is regulated by multiple proteins, which either directly bind to RNA or form multi-protein complexes. The RNA-binding protein ZC3H11A is involved in nuclear mRNA export, and NF-κB signaling and is essential during mouse embryo development. Furthermore, previous studies have s...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042238 | Pride
Zinc finger protein Pabpn1 Zc3h11a Adenovirus Polyadenylation 
ProteomicsDiscovery of RUF6 ncRNA interacting proteins involved in P. falciparum immune evasion
RUF6 is a ncRNA gene family that is transcribed by RNA Polymerase III but actively regulates the Pol II-transcribed var virulence gene family. Understanding how RUF6 ncRNA connect to downstream effectors is lacking. We developed an RNA-directed proteomic discovery (ChIRP-MS) protocol to identify in ...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-11-15 | PXD036801 | Pride
Var genes Malaria virulence Ruf6 ncrna Plasmodium falciparum Antigenic variation 
ProteomicsSystematic analysis of human nuclear protein complexes by quantitative mass spectrometry profiling
Many proteins form stable complexes that coordinate diverse and complex cellular processes. Systematic analysis of protein complexes provides insights into how the ensemble of expressed proteome is organized into functional units. Protein complexes are usually identified using either yeast-two-hybri...
ORGANISM(S): Human Gbm Cell Lines 
MSV000081520 | MassIVE
ProteomicsIdentification of Alpha-Synuclein Interacting Synaptosomal Proteins
α-Synuclein is an abundant presynaptic protein that when aggregated and dyslocated from the synapse is associated to Parkinson’s disease and dementia. The normal presynaptic function of α-synuclein is unclear as well as the disease triggering mechanism. In order to extend the knowledge of the α-synu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2015-02-09 | PXD001462 | Pride
Aggregation Synaptosomes Protein-protein interactions Proteomics Alpha-synuclein 
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