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UnknownValidation of an Echidna Forelimb Musculoskeletal Model Using XROMM and diceCT.
Not available
S-EPMC8606742 | biostudies-literature
UnknownBroad similarities in shoulder muscle architecture and organization across two amniotes: implications for reconstructing non-mammalian synapsids.
Not available
S-EPMC7034385 | biostudies-literature
UnknownMusculoskeletal modeling of sprawling and parasagittal forelimbs provides insight into synapsid postural transition.
Not available
S-EPMC10441569 | biostudies-literature
ProteomicsQuantitative phosphoproteomic for CDKL5 substrates
Global phosphoproteomic screen to identify the first cellular substrates of CDKL5. CDKL5 knock-out U2OS cells and CDKL5 wt U2OS cells were generated for the TMT-based phosphoproteomic. Thi leads to the identification and further validation of several phosphopetides of MAP1S, CEP131 and CDKL5 itself....
ORGANISM(S): Homo sapiens (Human) 
2018-09-24 | PXD009374 | Pride
Cdkl5 substrates Phosphoproteomic Tmt Ms2 
ProteomicsProteomics profiling of Neuronal Mitochondria
Mitochondria are the ‘power-houses’ of all cells, generating ATP to fuel numerous pathways which are vital for cellular form and function (1). Neuronal processes and synapses present a constant demand for ATP to maintain ionic gradients and neurotransmission events (2), promoting sub-populations of ...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD005537 | Pride
Neuron Proteomics Mitochondria Synapse Neurodegeneration 
ProteomicsDevelopment of a New N-Terminomic Method to Study the Pathodegradome of the Staphylococcus aureus V8 Protease in Human Neutrophils
Staphylococcus aureus is a notorious human pathogen that relies on an array of virulence factors to engender infection and evade the host-immune system. Among these are the secreted proteases, which promote pathogenesis by degrading host proteins and modulating host-defenses. Human neutrophils play ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD057551 | Pride
Degradomics Neutrophils Tags-cr Immune dysregulation. Staphylococcus aureus V8 protease 
ProteomicsNAIA for cysteine profiling in HepG2 cells, protein target identification of covalent ligand and studying cysteine oxidative modifications
New cysteine probes, N-acryloylindole-alkynes (NAIAs), have been developed. We have applied NAIA-5 for cysteine profiling in HepG2 cell lysates, and the results have been compared to the conventional cysteine probe iodoacetamide-alkyne (IAA). NAIA-5 allows identification of more ligandable Cys than ...
ORGANISM(S): Homo sapiens (Human) 
2023-06-14 | PXD041264 | Pride
Profiling ligandable cysteines and studying cysteine oxidative modifications in human liver cancer cells hepg2 by naia-5 using bruker timstof ms 
ProteomicsHydrogen sulfide sensitizes Acinetobacter baumannii to killing by antibiotics.
The production of endogenous hydrogen sulfide (H2S) has been shown to confer antibiotic tolerance in all bacteria studied to date. Therefore, this mediator has been speculated to be a universal defense mechanism against antibiotics in bacteria. This is assuming that all bacteria produce endogenous H...
ORGANISM(S): Acinetobacter baumannii AB_TG2631 
2021-06-08 | PXD020384 | Pride
Acinetobacter baumannii Hydrogen sulfide Amr 
ProteomicsANGPTL4 binds to leptin receptor to regulate ectopic bone formation and fat metabolism
Leptin protein was thought to be unique to leptin receptor (LepR), but the phenotypes of mice with mutation in LepR (db/db) and leptin (ob/ob) are not identical, and the cause remains unclear. Here, we show that db/db, but not ob/ob mice had defect in tenotomy-induced heterotopic ossification (HO), ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD043087 | Pride
Leptin receptor  angptl4  heterotopic ossification  fat metabolism 
ProteomicsQuantitative tyrosine phosphoproteomics of wild type and PTPRK KO tumour xenografts
TMT-based quantitation of tyrosine phosphoproteomes of wild type and PTPRK KO tumour xenografts to determine additional mechanisms of tumour suppression by receptor tyrosine phosphatase PTPRK
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD050617 | Pride
Tmt Phosphatase Ptprk Tyrosine phosphoproteomics Tumour xenografts 
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