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ProteomicsDirect glycan structure determination of intact N-linked glycopeptides by low-energy collision-induced association tandem mass spectrometry and predicted spectral library searching
Intact glycopeptide MS analysis to reveal site-specific protein glycosylation is an important frontier of proteomics. However, computational tools for analyzing MS/MS spectra of intact glycopeptides are still limited and not well-integrated into existing workflows. In this work, a novel computationa...
ORGANISM(S): Homo sapiens (Human) 
2016-08-17 | PXD002803 | Pride
Glycopeptide Lc-msms 
ProteomicsiPRG 2012: A Study on Detecting Modified Peptides in a Complex Mixture
This is the data and results associated with the 2012 study organized by the proteome informatics research group of the Association of Biomolecular Resource Facilities, which investigated participants' ability to identify a range of post-translationally modified peptides spiked into a yeast lysate b...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2013-11-19 | MSV000078492 | MassIVE
UnknownLong-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects.
Not available
S-EPMC9464237 | biostudies-literature
ProteomicsProteome Differences between Daptomycin-Resistant and WT MRSA Biofilms after Elasnin Treatment
A recent study reported that daptomycin-resistant MRSA (DAPR) strain biofilm is more resistant to daptomycin and vancomycin, as compared to the WT strain biofilm. This pose a great danger since DAPR MRSA is prevalent in clinics and they often form biofilms in medical devices. In this study, we inves...
ORGANISM(S): Staphylococcus aureus 
2021-11-11 | PXD024005 | Pride
Daptomycin-resistant Mrsa Elasnin Biofilms 
ProteomicsProteomics Analysis of Evolved Escherichia coli Populations from Cyclic Antibiotic Treatment
When the survivors of antibiotic treatment (persisters) are repeatedly regrown and retreated with the same antibiotic for several cycles, the new population will soon adapt to the treatment condition and become tolerant to the drug. Here, we did evolution experiments on Escherichia coli populations ...
ORGANISM(S): Escherichia coli 
2020-01-10 | PXD013326 | Pride
Proteomics Persistence Antibiotic Persisters Evolved populations 
ProteomicsProteomics Analysis of Escherichia coli Persisters
Persisters, a dormant and multi-drug tolerant subpopulation that are able to resuscitate after antibiotic treatment, have recently received considerable attentions as the major risk of the relapse of various infectious diseases in clinics. However, due to their low abundance and inherent mutability,...
ORGANISM(S): Escherichia coli 
2018-10-16 | PXD010590 | Pride
Tolerant Proteomics Persistence Dormancy Antibiotic 
UnknownLRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease.
Not available
S-EPMC8842874 | biostudies-literature
ProteomicsProteomic Investigation of Multiple Methicillin-Resistant Staphylococcus aureus strains with distinct Daptomycin Tolerance and Resistance Phenotypes
Several groups have shown that through evolution experiments, tolerance and resistance evolved rapidly under cyclic antibiotic treatment. In other words, intermittent antibiotic exposure performed in a typical adaptive laboratory evolution (ALE) experiments will “train” the bacteria to become tolera...
ORGANISM(S): Staphylococcus aureus 
2022-07-14 | PXD026741 | Pride
Proteomics Daptomycin Methicillin-resistant staphylococcus aureus Adaptive laboratory evolution Tolerance 
ProteomicsProteomic Investigation of Evolved Daptomycin-Tolerant MRSA due to Mutation in YycH
Several groups have shown that through evolution experiments, tolerance and resistance evolved rapidly under cyclic antibiotic treatment. In other words, intermittent antibiotic exposure performed in a typical adaptive laboratory evolution (ALE) experiments will “train” the bacteria to become tolera...
ORGANISM(S): Staphylococcus aureus 
2022-07-16 | PXD031078 | Pride
Proteomics Daptomycin Methicillin-resistant s. aureus Adaptive laboratory evolution Tolerance Yych 
ProteomicsProteomic Study of Tolerant S. aureus Strains after Drug Combination Treatment
Several groups have shown that through evolution experiments, tolerance evolved rapidly under cyclic antibiotic treatment which then promote the emergence of resistance. In other words, intermittent antibiotic exposure will “train” the bacteria to become tolerant to the drug, and then boost the chan...
ORGANISM(S): Staphylococcus aureus 
2021-07-27 | PXD021667 | Pride
S. aureus Daptomycin Tolerance 
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