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ProteomicsIntegrative glycomic and proteomic analysis of mouse striatum and lateral hypothalamus following cocaine and methamphetamine treatment
Drug abuse is a major concern with few therapeutic options. Heparan sulfate (HS) and chondroitin sulfate (CS) interact with a plethora of growth factors and their receptors, and have profound effects on cellular signaling. Thus, targeting these dynamic interactions represents a novel therapeutic mod...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-04 | PXD038576 | Pride
Chondroitin sulfate Mass-spectrometry Lateral hypothalamus Striatum Glycomics Drug abuse Methamphetamine Cocaine Proteomics Addiction Glycosaminoglycans Heparan sulfate Neurobiology Proteoglycans 
TranscriptomicsTestosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice
Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin (KISS1) do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these proteins in the hypothalamus have yet to be explored by genome-wide methods. Using micro-disse...
ORGANISM(S): Mus musculus 
2011-08-21 | E-GEOD-28383 | biostudies-arrayexpress
ProteomicsThe hypothalamus is an early site of mitochondrial failure and neuro-immune circuit disruption in amyotrophic lateral sclerosis
Given the hypothalamus central role in energy homeostasis and its emerging vulnerability in ALS, this study aimed to determine whether hypothalamic mitochondrial dysfunction may contribute to and potentially drive disease-related metabolic disturbances, thereby representing a potential therapeutic t...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD070931 | Pride
Proteomics Mitochondria Als 
GenomicsLoss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors
Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors
PRJNA580049 | ENA
GenomicsAn MCH neuroendocrine circuit in lateral hypothalamus for bone mass regulation
An MCH neuroendocrine circuit in lateral hypothalamus for bone mass regulation
PRJNA1001845 | ENA
TranscriptomicsMouse hypothalamus and whole brain: control vs. sodium craving
Sodium appetite is an instinct that involves avid specific intention. It is elicited by sodium deficiency, stress-evoked ACTH and by reproduction. Genome-wide microarrays in sodium deficient mice, or following ACTH infusion, showed upregulation of hypothalamic genes, including DARPP-32, dopamine rec...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-29451 | biostudies-arrayexpress
TranscriptomicsIntracranial self-stimulation regulates gene expression in rat hippocampus
Transcriptional profiling of rat hippocampus 4.5h post intracranial self-stimulation (ICSS) show that this treatment, which improves learning and memory processes in a variety of paradigms of implicit and explicit memory, regulates gene expression of genes related to cAMP-mediated signaling and regu...
ORGANISM(S): Rattus norvegicus 
2013-09-03 | E-GEOD-42793 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat brain tissues from animals with varying levels of access to cocaine
By using high-density oligonucleotide arrays, we profiled gene expression in reward-related brain regions of rats that developed escalated cocaine intake after extended access to cocaine (6 h per day). Rats allowed restricted daily access to cocaine (only 1 h) that displayed a stable level of cocain...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-3016 | biostudies-arrayexpress
UnknownLateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety.
Not available
S-EPMC10005966 | biostudies-literature
UnknownResting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study.
Not available
S-EPMC6072838 | biostudies-literature
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