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ProteomicsProtein Interactions of 7 MLL-fusion Proteins
MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL protein. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain p...
ORGANISM(S): Homo sapiens (Human) 
2018-05-25 | PXD009338 | Pride
Mll-fusion Leukemia Human 
ProteomicsEvaluating cPILOT Performance on Orbitrap Instruments
A global cPILOT assay developed on an Orbitrap Velos instrument was transitioned to an Orbitrap Fusion Lumos instrument. Parameters such as the LC gradient, m/z isolation window, dynamic exclusion, targeted mass analyses, and SPS-N were optimized. The number of proteins identified on the Fusion Lumo...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD012133 | Pride
Proteomics Fusion lumos Alzheimer's disease Multiplexing Cpilot 
ProteomicsHuman- lung squamous cell carcinoma LC-MS/MS Orbitrap Fusion
Integration of LC-MS/MS data links biological processes to fragmentation of tumor epithelia, and morphological marker that associates with decreased patient survival in lung squamous cell carcinoma
ORGANISM(S): Homo sapiens (Human) 
2017-05-15 | PXD006132 | Pride
Human Lung squamous cell carcinoma Fusion 
ProteomicsInteractome profile of the global regulator YmdB in Bacillus subtilis
To investigate the interacting protein partners of the global regulator YmdB from Bacillus subtilis, co-immunoprecipitation was performed using an N-terminal HA-tagged YmdB expressed from its native chromosomal locus under an endogenous promoter. The interactome complexes were analyzed by LC-MS/MS o...
ORGANISM(S): Bacillus subtilis 
2026-08-28 | PXD069961 | Pride
Co-immunoprecipitation Bacillus subtilis Protein-protein interaction Ymdb Orbitrap fusion 
ProteomicsSARS-CoV-2 infection of human lung epithelial cells induces TMPRSS-mediated acute fibrin deposition
Twenty microliter aliquots of BALF samples were dissolved in SDS-sample buffer and applied onto a 4-12% Nupage gel with MOPs running buffer. The run stopped after the samples migrated approximately ¼ distance into the gel. Each lane of the gel was sliced into smaller pieces, and subjected to destai...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD045119 | Pride
Nhbe cells Fibrin deposit Sars-cov-2 infection Bronchoalveolar lavage 
ProteomicsInteractome of the TCF3-HLF fusion protein
Oncogenic chimeric transcription factors are central drivers in cancer. To understand how the TCF3-HLF fusion protein rewires the transcriptional landscape in t(17;19) positive leukemia, functional genetic and proteomic experiments were conducted. In this dataset, the protein-protein interactions of...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD014992 | Pride
Flag-tagged fusion protein Ap-ms 
ProteomicsTurboID of EWS-FLI1 and EWS-P3 fusion proteins
TurboID of EWS-FLI1 and EWS-P3 fusion proteins coupled with nanoscale capillary chromatography and label free quantitation.
ORGANISM(S): Homo sapiens (Human) 
2026-03-26 | PXD051746 | Pride
Bioid Label free 
MetabolomicsA Multi-omics Longitudinal Study Reveals Alteration of the Leukocyte Activation Pathway in COVID-19 Patients
Severe coronavirus disease 2019 (COVID-19) infection may lead to lung injury, multi-organ failure, and eventually death. Cytokine storm due to excess cytokine production has been associated with fatality in severe infections. However, the specific molecular signatures associated with the elevated im...
2022-01-18 | MTBLS2469 | MetaboLights
UnknownSelenoproteome Identification in Inflamed Murine Primary Bone Marrow-Derived Macrophages by Nano-LC Orbitrap Fusion Tribrid Mass Spectrometry.
Not available
S-EPMC6592718 | biostudies-literature
ProteomicsHuman and Rat Serum Proteome from Orbitrap Fusion LUMOS
LC-MS/MS raw data acquired using commercially available abundant protein depletion columns using serum of normal human and non-injured rat acquired on Orbitrap Fusion Lumos Mass Spectrometer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Rattus (ncbitaxon:10114) 
2020-02-25 | MSV000085008 | MassIVE
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