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ProteomicsIn-depth proteome analysis of renal fibrosis in primary cultured human-derived kidney cells
Biomarker assessments based on kidney tissue evaluations show a direct correlation with renal fibrosis, but are limited by their invasive nature. Consequently, there is a growing interest in noninvasive biomarkers based on urine and blood samples. However, the utility of urine samples is limited by ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD043922 | Pride
Htec Tmt Renal fibrosis 
UnknownPreoperative cardiac troponin level is associated with all-cause mortality of liver transplantation recipients.
Not available
S-EPMC5441610 | biostudies-literature
UnknownA Multicenter Randomized Phase II Study of Docetaxel vs. Docetaxel Plus Cisplatin vs. Docetaxel Plus S-1 as Second-Line Chemotherapy in Metastatic Gastric Cancer Patients Who Had Progressed after Cisplatin Plus Either S-1 or Capecitabine.
Not available
S-EPMC5512362 | biostudies-literature
ProteomicsDIA-based Proteomic analysis of human islets with treatment of a PERK inhibitor
Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucida...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD074587 | Pride
Human Islets Dia Perk inhibitor 
ProteomicsProteomic analysis on human islet with treatment of a PERK inhibitor
Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucida...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD066613 | Pride
Tmt Perk inhibitor Islet 
Unknown22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα.
Not available
S-EPMC6084351 | biostudies-literature
ProteomicsInteractome analysis of Adenylyl cyclase-associated protein 1
The direct inflammatory action of proprotein convertase subtilisin/kexin type 9 (PCSK9) is examined in vitro in monocytes and endothelial cells, as well as via an in vivo atherosclerosis animal model. PCSK9 exacerbates atherosclerosis in low-density lipoprotein receptor (LDLR)-/- mice, indicating an...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD047058 | Pride
Cap1 Human Interactome Pcsk9 
ProteomicsTMT 10-plex based quantitative proteomic analysis of drug resistant breast cancer cell lines
Breast cancer accounts for roughly 30% of all cancers in women worldwide, has a 15% death rate, and incidence rates are increasing at a rate of about 0.5% per year. Breast cancer comprises a heterogeneous group of tumor subtypes, whether defined by the histopathology of the primary tumor, the expres...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030881 | Pride
Human Tmt Breast cancer Drug resistance 
UnknownWafer-Bonded AlGaInP Red LEDs with Suppressed S-Droop through Surface Sulfidation.
Not available
S-EPMC12903108 | biostudies-literature
Proteomicsproteomic landscape of urothelial tumor
Inverted papilloma (IP) of the urinary bladder is a relatively rare neoplasm that accounts for < 1% of bladder tumor. Although generally accepted as a benign lesion, occasional reports of IP admixed with urothelial carcinoma (UC) or IP patients with synchronous or metachronous UC have raised a conce...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027602 | Pride
Human Urothelial tumor Ffpe Label free quantification 
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