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ProteomicsiTRAQ-Based Quantitative Proteomic Comparison of 2D and 3D Adipocyte Cell Models Co-cultured with Macrophages Using Online 2D-nanoLC-ESI-MS/MS
The demand for novel three-dimensional (3D) cell culture models of adipose tissue has been increasing, and proteomic investigations are important for determining the underlying causes of obesity, type II diabetes, and metabolic disorders. In this study, we performed global quantitative proteomic pro...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD014437 | Pride
3d-culture Macrophages Adipocytes Proteomic quantification Itraq 
ProteomicsATAD5 regulates R-loop by maintaining RNA helicase level and unloading PCNA at the replication fork
R-loops are formed when replicative forks collide with the transcriptional machinery and can cause genomic instability. However, it is unclear how R-loops are regulated at transcription-replication conflicts (TRC) sites and how replisome proteins are regulated to prevent R-loop formation or mediate ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018207 | Pride
Dead-box rna helicase Atad5 R-loop Replication stress Pcna 
ProteomicsProteomic analysis of Cerebral organoid-derived exsome
In this study, we provides a comprehensive analysis of proteomic changes in exosomes derived from cerebral organoids during neuronal differentiation.
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD063105 | Pride
Exosome Cerebral organoids Proteome 
ProteomicsRibonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules
Circular RNAs (circRNAs) accumulate with age, but their functional impact on aging remains elusive. In this study, we reveal a mechanism by which ribonuclease κ (RNASEK) prevents age-dependent circRNA accumulation by promoting its degradation. Through a genetic screen targeting ribonucleases, we ide...
ORGANISM(S): Caenorhabditis Elegans 
2026-01-15 | PXD073097 |
UnknownUpregulation of Low-Density Lipoprotein Receptor of the Steroidogenesis Pathway in the Cumulus Cells Is Associated with the Maturation of Oocytes and Achievement of Pregnancy.
Not available
S-EPMC8465166 | biostudies-literature
UnknownBipolar disorder and the risk of cardiometabolic diseases, heart failure, and all-cause mortality: a population-based matched cohort study in South Korea.
Not available
S-EPMC10803345 | biostudies-literature
UnknownDepression, antidepressant use, and the risk of type 2 diabetes: a nationally representative cohort study.
Not available
S-EPMC10731300 | biostudies-literature
UnknownA case of early diagnosis of pulmonary capillary hemangiomatosis in a worker with exposure to silica.
Not available
S-EPMC6651969 | biostudies-literature
UnknownAssociation Between Antibiotic Exposure, Bronchiolitis, and TLR4 (rs1927911) Polymorphisms in Childhood Asthma.
Not available
S-EPMC4341338 | biostudies-literature
UnknownLoss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
Not available
S-EPMC6158508 | biostudies-literature
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