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ProteomicsA Systems biology approach for defining the potential molecular framework of hypereosinophilic syndrome with cutaneous involvement
Hypereosinophilic syndrome (HES) is a rare multisystem disease that predominantly includes skin with severe and persistent itching. A lack of understanding about the pathological condition and mechanism of dermatosis caused by HES hinders its treatment. In the present study, we applied a quantitativ...
ORGANISM(S): Homo Sapiens 
2020-02-18 | PXD015450 |
ProteomicsA Study on the Inflammatory Response of the Brain in Neurosyphilis
Neurosyphilis (NS) is a clinical condition caused by infection of the central nervous system (CNS) by Treponema pallidum (Tp) that can lead to asymptomatic meningitis and more serious neurological diseases, such as dementia and blindness. However, current studies on the pathogenesis of NS are limite...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053294 |
Proteomicshippocampus LC-MS experiment from Men1-CcKO mice and the controls
hippocampus dissection and conducted the LC-MS experiment in double-blind conditions
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD042795 | Pride
Hippocampus Lc-ms 
ProteomicsSARS-CoV-2-Infected hiPSC-Derived Cardiomyocytes Reveal Dynamic Changes in the COVID-19 Hearts
The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. Moreover, the disease’s extensive and sustained symptoms are now becoming a nonnegligible medical challenge. In this respect, data show that heart failure is one of the most common readmission diagn...
ORGANISM(S): Homo Sapiens 
2023-12-01 | PXD047427 |
ProteomicsProteomic identification of new diagnostic biomarkers of early-stage cutaneous mycosis fungoides
Primary cutaneous T-cell lymphoma (CTCL) is responsible for two-thirds of cutaneous lymphoma cases. Mycosis fungoides (MF), the most common subtype of CTCL comprises approximately 60% of CTCLs. Due to the similar clinical features of MF and inflammatory diseases such as eczema and psoriasis, early-s...
ORGANISM(S): Homo Sapiens 
2020-11-28 | PXD022798 |
ProteomicsTime-resolved extracellular matrix atlas of the developing human skin dermis
Skin aging is a physiological problem that remains a concern. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging; however, changes in ECM characteristics and molecules that are secreted to the extracellular space and involved in the formation of ...
ORGANISM(S): Homo Sapiens 
2022-11-28 | PXD016440 |
ProteomicsApplication of an iPSC-derived Organoid Model for Located Scleroderma Therapy
Scleroderma is a chronic connective tissue disease characterized by skin thickening and plaque morphea, as well as hard, shiny skin. Serious involvement is observed from the superficial dermis down to the fascia and muscle. However, this condition is difficult to treat and evaluate. In this study, i...
ORGANISM(S): Mus Musculus 
2021-04-26 | PXD025613 |
ProteomicsLarge-scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis
Neurosyphilis (NS) is a central nervous system infection caused by Treponema pallidum. NS can occur at any stage of syphilis and manifests as a broad spectrum of clinical symptoms. Often referred to as “the great imitator”, NS can be easily overlooked or misdiagnosed due to the absence of standard d...
ORGANISM(S): Homo Sapiens 
2024-02-16 | PXD033034 |
Proteomics5xFAD mitochondrial Data-independent acquisition
islation of AD mitochondrial and then detect the changes
ORGANISM(S): Mus Musculus 
2022-04-03 | PXD032992 |
ProteomicsSpatial-region-resolved proteomic map reveals mechanism of COVID-19-associated heart injury
Coronavirus disease 2019 (COVID-19) induces diverse clinical manifestations accompanied by multi-organ dysfunction. Of these, heart complications are the most life threatening. Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drive systemic ...
ORGANISM(S): Homo Sapiens 
2022-01-26 | PXD031249 |
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