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UnknownThe nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.
Not available
S-EPMC556282 | biostudies-literature
UnknownA large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene.
Not available
S-EPMC3125974 | biostudies-literature
UnknownGenetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway.
Not available
S-EPMC2525560 | biostudies-literature
ProteomicsUBA80 and UBA52 regulate DNA damage repair by targeting RNF168-dependent ubiquitination of H2A/H2AX
Tandem affinity purification of RNF168 and various RNF168 mutants to identify interacting proteins involved in DNA damage repair.
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD037840 | Pride
Dna damage Rnf168 Ubiquitin 
UnknownArp2/3-independent assembly of actin by Vibrio type III effector VopL.
Not available
S-EPMC2040399 | biostudies-literature
UnknownLoss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease.
Not available
S-EPMC5382316 | biostudies-literature
ProteomicsMolecular characterization of a complex of Apoptosis Inducing Factor 1 (AIFM1) with cytochrome c oxidase of the mitochondrial respiratory chain
Combining mass spectrometry based chemical cross-linking and complexome profiling, we analyzed the interactome of heart mitochondria. We focused on complexes of oxidative phosphorylation and found that dimeric apoptosis inducing factor 1 (AIFM1) forms a defined complex with ~10% of monomeric cytochr...
ORGANISM(S): Bos taurus (Bovine) 
2021-09-09 | PXD025102 | Pride
Structural docking Cox Aifm1 Xl-ms Bovine heart mitochondria 
MetabolomicsRisk assessment with gut microbiome and metabolite markers in NAFLD development
A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut microbiome in early detection of NAFLD is unclear. Prospective studies are necessary for identifying reliable, microbiome markers fo...
2022-07-11 | MTBLS2615 | MetaboLights
ProteomicsCryo-electron microscopy unravels microtubule inner protein networks reinforcing mammalian sperm flagella
To find and fuse with the egg, mammalian sperm must complete an arduous voyage through the female reproductive tract. This odyssey is powered by the sperm tail, a specialized motile cilium. Mammalian sperm tails are reinforced at the molecular scale with sperm-specific microtubule inner proteins (sp...
ORGANISM(S): Bos taurus (Bovine) 
2023-06-20 | PXD035941 | Pride
Sperm Proteomics Crosslinking ms Tubulin Dsso 
ProteomicsSpatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function
The sialomucin Podocalyxin (PODXL) is required for normal tissue development and apicobasal cell polarity by promoting lumen formation. Remarkably, high PODXL expression is also associated with metastasis and poor clinical outcome in multiple tumour types, such as prostate cancer. We performed exten...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032911 | Pride
Prostate cancer Iinteractome Invasion Podocalyxin 
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