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MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
ProteomicsComparative proteomics of fresh sperm and frozen sperm collected by electric stimulation method and Artificial vagina method
This progect included TMT-based proteomics and PRM proteomics. The study aimed to we aimed to investigate the differential impact of rectal probe electrostimulation and artificial vagina semen collection methods on the quality and the freezing tolerance of goat sperm.
ORGANISM(S): Capra Hircus 
2023-11-29 | PXD047354 |
TranscriptomicsInsights into the invasiveness of triple negative breast cancer from genome-wide profiling of transcription factor AP-1 (expression)
Triple negative breast cancer (TNBC) is an aggressive clinical phenotype, and accounts for 15% to 20% of all breast cancers. The molecular determinants of malignant cell behaviors in TNBC remain largely unknown. We find that the AP-1 transcription factor component, Fra-1, is overexpressed in basal-l...
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-46440 | biostudies-arrayexpress
UnknownInsights into the invasiveness of triple negative breast cancer from genome-wide profiling of transcription factor AP-1 (expression)
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-46440 | biostudies-other
TranscriptomicsRoles of RDR701 and DCLs in Rice PhasiRNA biogenesis
In this study, we analyzed function of the rice RDR701 and various DCLs proteins in small RNA processing. small RNA deep sequencing analyses revealed that RDR701 and OsDCL4 is involved in tasiRNAs and 21- and 24-nt phasiRNAs biogenesis. Further analyses indicate RDR701 coupling with OsDCL4 and OsDCL...
ORGANISM(S): Oryza sativa 
2012-07-02 | E-GEOD-26405 | biostudies-arrayexpress
ProteomicsRHOF Activation of AKT/β-Catenin Signaling Pathway Drives Acute Myeloid Leukemia Progression and Chemotherapy Resistance
To further investigate which molecules interact with RHOF in AML，we performed a comparative proteomic analysis of 293T cells overexpressing RHOF and control cells using liquid chromatography‒mass spectrometry.
ORGANISM(S): Homo Sapiens 
2024-05-09 | PXD052126 |
ProteomicsProteogenomic Characterization Reveals Tumorigenesis and Progression of Lung Adenocarcinoma Manifested as Subsolid Nodules
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. However, precise clinical management of SSNs requires thorough understanding of its tumorigenesis and progression. Here, we analyzed 66 LUAD displayed as SSNs covering 3 histological stages including adenoca...
ORGANISM(S): Homo sapiens (Human) 
2025-02-10 | PXD046637 | Pride
Lung adenocarcinoma  proteomic Phosphoproteomic  glycoproteomic 
ProteomicsATR-dependent phosphorylation of the histone acetyltransferase HBO1 suppresses chromatin binding and promotes replication stress responses.
This dataset contains label-free immunoprecipitation mass spectrometry (IP-MS) data to identify interacting partners of target proteins in human cell lines. Two sample groups (OMM2.3-input, OMM2.3-IP) were generated via co-immunoprecipitation with anti-HBO1 antibody. All LC-MS/MS proteomic detection...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD081136 | Pride
Atr Histone acetyltransferase Phosphorylation Hbo1 Replication stress 
ProteomicsStreptococcus suis SC-19, LC-MSMS
Phosphoproteomic analysis to identify deregulated phosphoproteins in stk mutant strain compared to the parental wild type strain SC-19
ORGANISM(S): Streptococcus suis 
2017-03-27 | PXD005663 | Pride
Streptococcus suis sc-19 Lc-msms 
MetabolomicsSerum metabolomic profiles for distinguishing lung cancer from pulmonary tuberculosis: identification of rapid and noninvasive biomarker

BACKGROUND: Pulmonary tuberculosis (TB) and lung cancer (LC) have similar clinical symptoms and atypical imaging findings which are easily misdiagnosed. There is an urgent need for a noninvasive, rapid and accurate biomarker for distinguishing LC from TB.

METHODS:

2024-01-16 | MTBLS6990 | MetaboLights
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