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MetabolomicsAlterations of fecal microbiota and plasma metabolome in patients with Parkinson's disease with rapid eye movement sleep disorder

Objectives: Patients with Parkinson's disease (PD) with probable Rapid eye movement sleep Behavior Disorder (RBD) (PD-RBD), a specific subtype of PD, is characterized by the presence of more severe motor and non-motor symptoms. This study aimed to elucidate the characteristics and interactions of...

2025-05-07 | MTBLS11094 | MetaboLights
UnknownAndrographolide Suppresses the Growth and Metastasis of Luminal-Like Breast Cancer by Inhibiting the NF-κB/miR-21-5p/PDCD4 Signaling Pathway.
Not available
S-EPMC8261247 | biostudies-literature
ProteomicsProtein sequencing of human bone tissue at different ages
Bone is a dynamic organ in which bone formation mediated by osteoblasts balances against bone resorption mediated by osteoclasts to maintain bone homeostasis. With age, this balance gradually tilts toward bone resorption, leading to bone loss and osteoporosis. At the present study, the bone specimen...
ORGANISM(S): Homo sapiens (Human) 
2023-02-01 | PXD039538 | Pride
Bone Osteoporosis Human Proteome Aging 
MetabolomicsVisceral obesity-Induced METTL27 regulation of the FABP5/PPARD/CPT1A axis in promoting colorectal cancer progression

The incidence of obesity and colorectal cancer (CRC) is rising annually. Obesity, particularly visceral obesity, poses a serious health threat, yet the association of obesity with CRC progression, as well as the role of visceral obesity, remains debated. This study analyzed 394 CRC patients ...

2025-10-06 | MTBLS13095 | MetaboLights
MetabolomicsLegume rhizodeposition promotes nitrogen fixation by soil microbiota under crop diversification

Biological nitrogen fixation by free-living bacteria and rhizobial symbiosis with legumes plays a key role in sustainable crop production. Here, we study how different crop combinations influence the interaction between peanut plants and their rhizosphere microbiota via metabolite deposition and ...

2024-03-19 | MTBLS6537 | MetaboLights
ProteomicsP. micra surface protein TmpC interacts directly with OSCC cell lines via CKAP4
P. micra surface protein TmpC interacts directly with OSCC cell lines via CKAP4, a receptor frequently overexpressed in human OSCC tumors. The interaction of TmpC and CKAP4 mediates bacterial attachment, invasion, and metastasis-promoting effects of P. micra on OSCC and subsequently activates HIF-1α...
ORGANISM(S): Homo Sapiens 
PXD054166 |
ProteomicsProteomic and Acetylome Alterations in Obesity-related Osteoarthritic Mouse Cartilage
Male mice aged 4 weeks were housed under controlled conditions and assigned to either a normal diet or a high-fat diet for 16 weeks to establish an obesity model. At 12 weeks, osteoarthritis was induced using the destabilization of the medial meniscus procedure under anesthesia, while sham-operated ...
ORGANISM(S): Mus Musculus 
PXD062707 |
Proteomicsinteractome and proteomic survey of PMBCs from COVID-19 patients
Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
ORGANISM(S): Homo Sapiens 
PXD020067 |
ProteomicsReconstitution of Pluripotency from Mouse Fibroblast through Sall4 Overexpression
We report that SALL4 alone, under an optimized reprogramming medium iCD4, is capable of reprogramming mouse fibroblasts into iPSCs. To identify SALL4-direct-interacting proteins, we performed immunoprecipitation followed by mass spectrometry (IP-MS) using MEFs overexpressing WT-SALL4 or SALL4 mutan...
ORGANISM(S): Mus Musculus 
2024-11-05 | PXD057516 |
ProteomicsHSPA1A and DNAJB1 regulate NELF condensate reversibility to safeguard transcriptional recovery under heat stress
The negative elongation factor (NELF) is essential in establishing RNA Polymerase II (Pol II) pausing at promoter-proximal regions, providing a key regulatory checkpoint for precise gene expression control. In response to heat shock (HS) stress, NELF has been observed to form nuclear condensates, bu...
ORGANISM(S): Homo Sapiens 
PXD064175 |
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