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TranscriptomicsDifferential IFNa-stimulated gene expression profiles in PLZF-inducible U937T monocyte cells
Sensitivity to Interferon (IFN) is determined by a complex coordination of genetic and environmental factors. A previous experiment using two renal cancer cell lines differing markedly in their response to IFN were analyzed for their ISG profiles in order to determine gene expression changes associa...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-16196 | biostudies-arrayexpress
UnknownSabotaging of the oxidative stress response by an oncogenic noncoding RNA.
Not available
S-EPMC5240659 | biostudies-literature
UnknownmiR-27b controls venous specification and tip cell fate.
Not available
S-EPMC3311282 | biostudies-literature
UnknownUSP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
Not available
S-EPMC6071563 | biostudies-literature
ProteomicsUnique Histone Proteoforms by Differential Top Down MS
H3.1 and H3.3 quadrupole isolated and fragmented by ETD and EThcD on an Orbitrap Fusion Lumos. Comparison of two cell lines.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-14 | MSV000079191 | MassIVE
UnknownBlood-brain barrier permeability in survivors of immune-mediated thrombotic thrombocytopenic purpura: a pilot study.
Not available
S-EPMC8945621 | biostudies-literature
UnknownComprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
Not available
S-EPMC2798864 | biostudies-literature
ProteomicsIdentification of the E3 ligase(s) recruited by 955 to degrade CDK9
PROTACs induce the degradation of target proteins by hijacking an E3 ligase. However, it is usually difficult to directly identify the E3 ligase recruited by a new E3 ligase ligand in a PROTAC using the co-immunoprecipitation method because the formation of the complex is transient and very dynamic....
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039401 | Pride
Turboid Protac Pl Cdk9 E3 ligase 
ProteomicsPiperlongumine (PL) conjugates induce targeted protein degradation
PROteolysis Targeting Chimeras (PROTACs) are bifunctional molecules that degrade target proteins through recruiting E3 ligases. However, their application is limited in part because few E3 ligases can be recruited by known E3 ligase ligands. In this study, we identified piperlongumine (PL), a natura...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039385 | Pride
Piperlongumine Protac E3 ligase Cdk9 
ProteomicsHDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis
Melanomas are heterogeneous and adopt multiple transcriptional states that can confer an invasive phenotype and resistance to therapy. Little is known about the epigenetic drivers of these cell states, limiting our ability to regulate melanoma heterogeneity and tumor progression. Here we identify st...
ORGANISM(S): Homo sapiens (Human) Brassica oleracea var. botrytis (Cauliflower) 
2023-09-26 | PXD044471 | Pride
Brain metastasis Melanoma Hdac8 Acetylation 
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