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ProteomicsMicroglial proteomic signatures in APPPS1 and APP-KI mice
Microglial dysfunction is a key pathological feature of Alzheimer´s disease (AD), but little is known about proteome-wide changes in microglia during the course of AD pathogenesis and their consequences for microglial function. Here, we performed an in-depth proteomic characterization of microglia i...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-09 | PXD016075 | Pride
Neuroinflammation Phagocytosis Alzheimer’s disease Proteomic signatures Microglia 
ProteomicsLncRNA RUS shapes the gene expression program towards neurogenesis
The evolution of brain complexity correlates with an increased expression of long, non-coding (lnc) RNAs in neuronal tissues. Although prominent examples illustrate the potential of lncRNAs to scaffold and target epigenetic regulators to chromatin loci, only few cases have been described to function...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-21 | PXD031664 | Pride
Rna protein interaction 
ProteomicsProteomics of cerebrospinal fluid (CSF) of acitretin treated patients
Acitretin has been shown to increase ADAM10 expression. In a phase II clinical trial, Alzheimer's disease patients were treated with acitretin or placebo to increase ADAM10 levels to counteract amyloid beta production. Analysis of the cerebrospinal fluid of from 18 AD patients treated with the synth...
ORGANISM(S): Homo sapiens (Human) 
2019-04-06 | PXD010756 | Pride
Alzheimer disease Csf Acitretin 
ProteomicsNeuronal differentiation of LUHMES cells is accompanied by substantial changes of the proteome
To study mechanisms of neurodegenerative diseases, neuronal cell lines are important model systems and are often differentiated into postmitotic neuron-like cells to resemble more closely primary neurons obtained from brains. One such cell line is the Lund Human Mesencephalic (LUHMES) cell line whic...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-09-24 | PXD020044 | Pride
Luhmes cells Dopaminergic neuron Murine midbrain neurons Parkinson’s disease 
ProteomicsMouse CSF analysis of 3, 6, and 12 months old mice in comparison to human CSF
Mice are the most commonly used preclinical animal model, but protein analytics of murine cerebrospinal fluid (CSF) remains challenging because of low CSF volume (often <10 µl) and frequent blood contaminations. We developed an improved CSF sampling method that allows routine collection of increased...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-04-15 | PXD053698 | Pride
Cerebrospinal fluid Csf Mouse Human 
ProteomicsPerilous Sites: High basic Fibroblast Growth Factor level supplement Parkinson’s disease pathology and its Spread
Lewy body (LB) pathology and loss of dopaminergic neurons are imprints of Parkinson’s disease (PD). LBs are mainly comprised of alpha-Synuclein (Dijkstra et al., 2014). Strolling detection of LBs in brain regions contribute to progressive construct of PD pathology to which molecular mechanisms are n...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-07-21 | PXD015969 | Pride
Neuron Exosome Bfgf Rat 
ProteomicsThe pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system
Proteolytic ectodomain shedding of membrane proteins is a fundamental mechanism to control the communication between cells and their environment. A key protease for membrane protein shedding is ADAM17, which requires a non-proteolytic subunit, either inactive Rhomboid 1 (iRhom1) or iRhom2 for its ac...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-07 | PXD028096 | Pride
Mouse Neuron Hispecs Csf 
ProteomicsProteomics of human iPSC derived dopaminergic neurons with a Parkinson's disease linked PARK7/DJ-1 mutation
Parkinson’s disease (PD) is characterized by α-synuclein accumulation and dopaminergic neuron degeneration, with dopamine (DA) oxidation emerging as a key pathological driver. However, the mechanisms underlying this neurotoxic process remain unclear. Using PD patient-derived and CRISPR-engineered iP...
ORGANISM(S): Homo sapiens (Human) 
2026-01-07 | PXD069663 | Pride
Vmat2 Dj-1 Parkinson’s disease Dopaminergic neurons Park7 Ipsc derived neurons 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067461 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067413 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
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