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ProteomicsHydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2
Cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation toward aerobic glycolysis. Pyruvate kinase M2 (PKM2), which converts phosphoenolpyruvate (PEP) to pyruvate, is considered the rate-limiting enzyme involved in cancer glucose metabolism. By reducing PKM2 enzyme acti...
ORGANISM(S): Homo sapiens (Human) 
2024-07-09 | PXD044925 | Pride
Glucose metabolism Pkm2 Lc-ms Oligomerization Sulfhydration Hydrogen sulfide 
UnknownImpacts of microRNA gene polymorphisms on the susceptibility of environmental factors leading to carcinogenesis in oral cancer.
Not available
S-EPMC3386241 | biostudies-literature
ProteomicsAn intrinsically disordered region of histone demethylase KDM5A regulates catalysis through interactions with the nucleosomal acidic patch and DNA
KDM5A lysine demethylase conformation was probed by BS3 crosslinking in the presence and absence of DNA. Crosslinked proteins were reduced, alkylated with iodoacetamide, trypsin digest, and labeled with TMT6plex reagent prior to mixing and acquisition on an Orbitrap Exploris equiped with a FAIMS sou...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-10 | MSV000097094 | MassIVE
ProteomicsStructural basis of the SWI/SNF-bound transcription pre-initiation complex
DSSO crosslinking of SwiSnf + Mediator + Pre-initiation Complex. Two replicate experiments starting with 300 ug of protein and 6 mM DSSO. Crosslinked peptides were fractionated by size-exclusion chromatography (SEC) and 8 SEC were analyzed by LC-MS on an Orbitrap Exploris 480 instrument. The first s...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2025-05-14 | MSV000097892 | MassIVE
UnknownAn enigma of hypothyroidism and hyponatremia coexistence: a nationwide population-based retrospective study.
Not available
S-EPMC10541708 | biostudies-literature
UnknownFour-and-a-Half LIM Domains Protein 2 Is a Coactivator of Wnt Signaling in Diabetic Kidney Disease.
Not available
S-EPMC4657839 | biostudies-literature
UnknownDevelopment of a Multiplexed Assay for Oral Cancer Candidate Biomarkers Using Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry.
Not available
S-EPMC5629267 | biostudies-literature
UnknownMethylmalonic acidemia/propionic acidemia - the biochemical presentation and comparing the outcome between liver transplantation versus non-liver transplantation groups.
Not available
S-EPMC6444613 | biostudies-literature
UnknownHydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2.
Not available
S-EPMC11358145 | biostudies-literature
UnknownASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain.
Not available
S-EPMC8510583 | biostudies-literature
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