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To assess the effect of CD25 (Il2ra) knockout on signaling in pre-B leukemia, pre-B cells from CD25-floxed mouse bone marrow were grown ex-vivo with IL-7 and transformed with BCR-ABL1, before tratment with 4-OHT to induce CD25 KO. Phospho-Tyrosine proteomics was performed and differential phosphosit...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD036128 | Pride
To assess the effect of CD25 (Il2ra) knockout on signaling in pre-B leukemia, pre-B cells from CD25-floxed mouse bone marrow were grown ex-vivo with IL-7 and transformed with BCR-ABL1, before treatment with 4-OHT to induce CD25 KO. Phosphoproteomics was performed and differential phosphosites analys...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD038996 | Pride
CD25-dificient patient-derived PDX2 B-ALL cells and Jeko1 MCL cells with CRISPR-Cas9-mediated gene deletion were reconstituted with wild-type CD25 (S268) or CD25 carrying S268A mutant (A268) with C-terminal BirA (engineered biotin ligase) and selected by puromycin for 3 days. BirA expressing constru...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD035989 | Pride
The MS data of Protein Lysine 43 Methylation by EZH1 Promotes AML1-ETO Transcriptional Repression Protein Lysine 43 Methylation by EZH1 Promotes AML1-ETO Transcriptional Repression
ORGANISM(S): Homo Sapiens 
2019-12-11 | PXD016712 |
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