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ProteomicsHigh-resolution proteomics of Zika and Dengue serum samples
We used data independent acquisition (DIA) mass spectrometry (MS) to profile ~800 proteinsfrom 122 serum samples Dengue or Zika Trinidadian patients. Two time points were collectedper patient. The DIA MS data were matched against a spectral library generated from high pH/low pH separated pooled seru...
ORGANISM(S): Homo sapiens (Human) 
2021-03-09 | PXD015422 | Pride
Dia Serum Dengue Zika 
TranscriptomicsTranscription profiling of Drosophila embryos shows the zinc finger protein Zelda plays a key role in the maternal to zygotic transition
In all animals, the initial events of embryogenesis are controlled by maternal gene products that are deposited into the developing oocyte. At some point after fertilization, control of embryogenesis is transferred to the zygotic genome in a process called the maternal to zygotic transition (MZT). D...
ORGANISM(S): Drosophila melanogaster 
2008-11-22 | E-GEOD-11231 | biostudies-arrayexpress
ProteomicsKinome profiling of osteosarcoma patient-derived xenograft TT2 treated with palbociclib
Osteosarcoma (OS) is the most common primary bone cancer in adolescents, young adults (AYA), and children, with up to 25% of patients developing metastatic disease, primarily in the lungs. Despite survival rates being >70% for localized tumors, patients with metastatic OS have <30% survival due to l...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD069093 | Pride
Kinase Inhibitor Bead Pi3k Cdk4/6 Mtor 
TranscriptomicsBiomarker analysis of neoadjuvant Doxorubicin/Cyclophosphamide followed by Ixabepilone or Paclitaxel in early-stage breast cancer
A randomized, open-label, multicenter, phase II trial (NCT00455533) enrolled previously untreated women with histologically-confirmed primary invasive breast adenocarcinoma (T2–3, N0–3, M0, tumor size ≥2.0 cm), regardless of hormone receptor or HER2 expression status. Patients received sequential ne...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-41998 | biostudies-arrayexpress
ProteomicsRepurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment
The myeloma bone marrow microenvironment drives proliferation of malignant plasma cells and promotes resistance to therapy. Interleukin-6 (IL-6) and downstream JAK/STAT signaling are thought to be central components of these microenvironment-induced phenotypes. In a prior drug repurposing screen, we...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006581 | Pride
Lc-msms Lfq Myeloma Bone marrow microenvironment Tofacitinib Human 
ProteomicsIdentification of GRAF1 interactome mediated by GRAF1 phosphorylation in response to Mitophagy
Defects in the clearance of dysfunctional mitochondria contribute to the development of heart failure and several neurological disorders including Parkinson’s disease (PD). The mitophagic signaling pathways that control the rapid recognition, ubiquitin-tagging and encasement of dysfunctional mitocho...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043212 | Pride
Heart Graf1 Pink1-parkin pathway Mitophagy 
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
TranscriptomicsTranscription profiling of mouse dendritic subsets in vivo
Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6259 | biostudies-arrayexpress
TranscriptomicsEvaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer
We evaluated the genome-wide microRNA expression profiles in lymphoblastoid cell lines of familial ovarian cancer patients and controls We used microarray to perform microRNA profiling in lymphoblastoid cell lines from 74 women with familial ovarian cancer patients and 47 controls.
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-31801 | biostudies-arrayexpress
GenomicsZelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation
A central question in biology is how enhancers are made accessible. The Drosophila embryo is a good model system to study this question as the gene regulatory networks regulating early developmental events have been well characterized. Zelda (Zld) is a uniformly distributed transcription factor (TF)...
ORGANISM(S): Drosophila melanogaster 
2015-08-21 | E-GEOD-65441 | biostudies-arrayexpress
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