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UnknownComprehensive Transcriptome-Metabolome Analysis and Evaluation of the Dark_Pur Gene from Brassica juncea that Controls the Differential Regulation of Anthocyanins in Brassica rapa.
Not available
S-EPMC8871995 | biostudies-literature
TranscriptomicsCellular reprogramming by the conjoint action of ERalpha, FOXA1, and GATA3 to a ligand inducible growth state
Despite the role of the estrogen receptor alpha (ERalpha) pathway as a key growth driver for breast cells, the phenotypic consequence of exogenous introduction of ERalpha into ERalpha-negative cells paradoxically has been growth inhibition. We map the binding profiles of ERalpha and its interacting ...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-30574 | biostudies-arrayexpress
ProteomicsProteomics detection of mouse embryonic 17.5 dpc cultured ovaries in vitro
In this project, the ovaries of mice at 17.5 dpc embryonic stage were collected, and KN93, an inhibitor of CAMKII, and IWP2, an inhibitor of Wnt5a, were added for in vitro culture. Proteins affected by KN93 and IWP2, which were regulated by CAMKII and Wnt5a, were detected by proteomics technology, s...
ORGANISM(S): Mus Musculus 
2022-07-07 | PXD035136 |
TranscriptomicsmRNA expression data from AG-haESC, E14 and MEF
Haploid cells are amenable for genetic analysis because they contain only one set of chromosomes.Here,we report the derivation of haESCs from androgenetic blastocysts. These cells, which we designated AG-haESCs, express classical ESC markers, are pluripotent, and contribute to various tissues includ...
ORGANISM(S): Mus musculus 
2012-04-26 | E-GEOD-35785 | biostudies-arrayexpress
TranscriptomicsExtensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped long-range chromatin interactions associated with RNA polymerase II in human cells and uncovere...
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-33664 | biostudies-arrayexpress
ProteomicsEZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation
Efforts to therapeutically target EZH2 have generally focused on inhibition of its methyltransferase activity, although it remains less clear whether this is the central mechanism whereby EZH2 promotes cancer. We demonstrate that EZH2 directly interacts with both MYC family oncoproteins, MYC and MYC...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029652 | Pride
Mycn Ap-ms Myc Ezh2 
ProteomicsStructural basis of RNA polymerase complexes in African swine fever virus
African swine fever virus is highly contagious and causes a fatal infectious disease in pigs, resulting in a significant global impact on pork supply. The African swine fever virus RNA polymerase serves as a crucial multifunctional protein complex responsible for genome transcription and regulation....
ORGANISM(S): African swine fever virus 
2025-02-14 | PXD058133 | Pride
Protein African swine fever virus Lc-msms 
ProteomicsTherapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability
Tumor cells must rewire nucleotide synthesis to satisfy the demands of unbridled proliferation. Meanwhile, they exhibit augmented reactive oxygen species (ROS) production which paradoxically damages DNA and free dNTPs. How these metabolic processes are integrated to fuel tumorigenesis remains to be ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD043444 | Pride
Myc Plk1 Nudt1 Cancer，protac 
ProteomicsCardiomyocyte-Derived HSPB1 Regulates TGF-β1 Maturation and Inhibits Endothelial-to-Mesenchymal Transition in Myocardial Fibrosis after Infarction
Myocardial fibrosis is a major contributor to heart failure after myocardial infarction (MI), primarily driven by endothelial-to-mesenchymal transition (EndoMT). Heat shock protein B1 (HSPB1) has cardioprotective functions, but its role in MI-induced fibrosis remains unclear. Here, we show that card...
ORGANISM(S): Homo Sapiens 
2025-12-22 | PXD072325 |
GenomicsGenome-wide TNFM-NM-1-induced p65 binding before and after telomerase inhibition in HeLa cells
Chromatin immunoprecipitation sequencing (ChIP-seq) was performed to analyze the effect of telomerase inhibition on TNFM-NM-1-induced genome-wide p65 binding in HeLa cells. By obtaining over 40 million uniquely mappable reads per sample from ChIP-seq, maps for TNFM-NM-1-induced p65 binding in absenc...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-41100 | biostudies-arrayexpress
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