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The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evidence for the MDOR in vivo is indirect and limited,...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD022106 | Pride
Ligand-dependent differences in the regulation and internalization of the mu-opioid receptor (MOR) have been linked to the degree of severity of the side effects that limit the use of opiates in the treatment of pain. For example, activation of the MOR by morphine and DAMGO ([D-Ala2,N-MePhe4,Gly-ol]...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD013328 | Pride
Schistosomiasis is a parasitic zoonosis which caused by schistosomes and poses great threat to the health of human and other mammals. Schistosome cercaria must penetrate skin as an initial step to successfully infect the final host. Proteolytic enzymes secreted from the acetabular glands of cercaria...
ORGANISM(S): Caenorhabditis elegans 
2017-05-08 | PXD002185 | Pride
The sample was removed from-80℃ and melted on ice. An appropriate amount of TEAB was added to adjust pH 8.0.5 μ L of suspension was used for SDS-PAGE testing.
ORGANISM(S): Homo sapiens (Human) 
2025-06-11 | PXD061479 | Pride
To better understand human ATP13A2-mediated polyamine transport, we used single-particle cryo-electron microscopy to solve high-resolution structures of human ATP13A2. Interestingly, we found polyamine binding at multiple sites distributed along the transmembrane regions in ATP13A2 protein, which ha...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037493 | Pride
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