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TranscriptomicsLong non-coding RNAs are differentially expressed in hepatocellular carcinoma cell lines with different metastatic potential
We describe the lncRNA expression profiles of two HCC cell lines, one with high potential for metastasis to the lung (HCCLM3) and the other to lymph nodes (HCCLYM-H2). The HCCLM3(LM3) and HCCLM6 cell lines were derived from the same parental cell line MHCC-97H. LM3 metastasizes to the lung, while HC...
ORGANISM(S): Homo sapiens 
2014-09-03 | E-GEOD-61015 | biostudies-arrayexpress
TranscriptomicsEndogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells
Small interfering RNAs (siRNAs) direct RNA interference (RNAi) in eukaryotes. In flies, somatic cells produce siRNAs from exogenous double-stranded RNA as a defense against viral infection. Here, we identify 21-nt long, endogenous siRNAs (endo-siRNAs) corresponding to transposons and heterochromatic...
ORGANISM(S): Drosophila melanogaster 
2008-04-10 | E-GEOD-11019 | biostudies-arrayexpress
UnknownThe MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese.
Not available
S-EPMC6048208 | biostudies-literature
UnknowniRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress.
Not available
S-EPMC6118040 | biostudies-literature
ProteomicsTemporal proteomics characterization of COVID-19 patient sera
We enrolled 37 SARS-CoV-2 positive patients including 17 short course (SC) COVID-19 patients (twice viral RNA detection negative over 24 hrs) and 20 COVID-19 long course (LC) COVID-19 patients. We also included 35 SARS-CoV-2 negative patients as control group. We collected 224 inactive serum samples...
ORGANISM(S): Homo Sapiens 
2022-07-26 | PXD035471 |
TranscriptomicsCharacterization of miRNA transcriptome of skeletal muscle from broiler and layer chicken lines by deep sequencing
In the current study, we expanded our previous work to identify miRNAs implicated in the myogenesis regulation through the comparison of miRNAs transcriptome in skeletal muscle tissues between broilers and layers. To address that, we firstly performed Solexa deep sequencing to profile miRNAs express...
ORGANISM(S): Gallus gallus 
2011-03-18 | E-GEOD-20942 | biostudies-arrayexpress
TranscriptomicsSpecific molecular signatures underlie response to decitabine in CMML
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-61163 | biostudies-arrayexpress
ProteomicsDNA2 and MSH2 activities collectively mediate environmental chemical compound stabilized G4 for efficient telomere replication
G-quadruplexes (G4s) are widely existing stable DNA secondary structures in mammalian cells. A long-standing hypothesis is that timely resolution of G4s is needed for efficient and faithful DNA replication. In vitro, G4s may be unwound by helicases or alternatively resolved via DNA2 nuclease-mediate...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059843 | Pride
G-quadruplex Msh2 Dna2 Telomere 
TranscriptomicsFetal lung development
Fetal lung development is a complex biological process, which involves temporal and spatial regulations of many genes. To understand molecular mechanisms of this process, we investigated gene expression profiling of lungs at gestational day 18, 19, 20, 21, new born, and adult rats using in-house rat...
ORGANISM(S): Rattus norvegicus 
2010-07-01 | E-GEOD-3302 | biostudies-arrayexpress
TranscriptomicsSpecific molecular signatures underlie response to decitabine in CMML [RNA-seq]
Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in epigenetic modifiers and aberrant DNA methylation. DNA methyltransferase inhibitors (DMTis) are used to treat these disorders, but response is highly variable with few means to predict which patien...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-61162 | biostudies-arrayexpress
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