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ProteomicsPhosphoprofile reorganization of the actin binding protein Drebrin during long term depression
Drebrin (DBN), an actin-binding protein critical for the structural integrity and function of dendritic spines, is highly phosphorylated at steady state in neurons. Here, we investigate the phosphorylation dynamics of DBN in the context of chemically induced long-term depression (cLTD), a synaptic p...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-17 | PXD069538 | Pride
Synaptic plasticity Drebrin Actin Long-term depression Phosphorylation Calpain 
TranscriptomicsExpression Profiling of a Genetic Animal Model of Depression
Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-like Behaviours In this study we have used genome-wide microarray expression profiling of the hippocampus and prefrontal/frontal cortex of Flinders Depression Sensitive (FSL) and cont...
ORGANISM(S): Rattus norvegicus 
2010-04-01 | E-GEOD-20388 | biostudies-arrayexpress
TranscriptomicsAntenatal Blood DNA Methylation Profiles
DNA methylation profiles were generating using Illumina HM450 microarrays in a prospective sample blood from the prenatal period of pregnant mood disorder patients who would and would not develop depression post partum. We recruited 54 pregnant women with a history of either Major Depression or Bipo...
ORGANISM(S): Homo sapiens 
2013-05-24 | E-GEOD-44132 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human entorhinal cortex cells from suicide patients with major depression.
RNAs were extracted from entorhinal cortex of human suicide patients with major depression and matched control subjects. The transcription profile was investigated by Agilent microarray platform and quantitative real-time PCR to reveal alterations in neuronal functions in this brain region.
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MEXP-2607 | biostudies-arrayexpress
ProteomicsAutophagic vesicle content profiling from hippocampal slices LC-MSMS
Previous work demonstrated that the developmental pruning of dendritic spines requires autophagy. This developmental process is facilitated by long-term depression (LTD)-like mechanisms, inviting the speculation that LTD, a fundamental form of plasticity, itself requires autophagy. Here, we show tha...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-10 | PXD030079 | Pride
Synaptic plasticity Autophagosome Cargo Long-term depression Autophagy 
ProteomicsQuantitative proteomics reveals the therapeutic effects of RFAP against depression
Label-free proteomics was used to find the therapeutic effect of traditional Chinese medicine RFAP against depression.
ORGANISM(S): Rattus Rattus 
PXD034278 |
TranscriptomicsRNA-seq of primary rat hypothalamic neurons by short- and long-term estrogen stimulation and withdrawal
Postpartum depression (PPD) is a prevalent neuroendocrine disorder triggered by the abrupt decline of estrogen after delivery. Estrogen withdrawal after delivery profoundly influences neurotransmission, synaptic plasticity, and neuroendocrine function within the hypothalamic pituitary gonadal (HPG) ...
ORGANISM(S): Rattus norvegicus 
2026-01-31 | E-MTAB-16415 | biostudies-arrayexpress
TranscriptomicsEstrogen Induced DNA Methylation Changes in Mouse Hippocampus
Estrogen, specifically estradiol, has been shown to mediate DNA methylation changes at mutiple locations downstream of estrogen response elements (EREs). We identified differentially methylated regions associated with long-term estradiol exposure in the hippocampus of C57BL/6J mice. Hippocampus was ...
ORGANISM(S): Mus musculus 
2013-05-24 | E-GEOD-43460 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles Predict Postpartum-onset Depression Patients with Treatment-Resistant Depression Patients with Treatment-Resistant Depression
To identify early predictive biomarkers for postpartum depression using peripheral blood gene expression profiles RNA was isolated from peripheral blood collected in Tempus RNA tubes (Applied Biosystems, Darmstadt, Germany) at all three investigated time points for each woman in the discovery sample...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-45603 | biostudies-arrayexpress
GenomicsThe impact of mild episodic ketosis on microglia and hippocampal long-term depression in 5xFAD mice
The impact of mild episodic ketosis on microglia and hippocampal long-term depression in 5xFAD mice
PRJNA1122134 | ENA
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