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MetabolomicsDeletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice
Deletion of the glycerol channel aquaporin-9 (Aqp9) reduces postprandial blood glucose levels in leptin receptor deficient (db/db) obese mice on a C57BL/6×C57BLKS mixed genetic background. Furthermore, shRNA mediated reduction of Aqp9 expression reduces liver triacylglycerol (TAG) accumulation in a ...
2015-09-28 | MTBLS219 | MetaboLights
ProteomicsMALDI rat liver anticancer drug spiked-in dataset (imzML)
For the MALDI-MSI experiment, we selected 12 different drugs. The drugs were purchased from the LC Laboratories (Woburn, MA; CAS numbers: dabrafenib: 1195765-45-7, dasatinib: 302962-49-8, erlotinib: 183321-74-6, gefitinib: 184475-35-2, imatinib: 152459-95-5, lapatinib: 388082-78-8, pazopanib: 444731...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-06 | PXD016146 | Pride
Imzml ground truth spiked-in drugs 
MetabolomicsRepurposing statins and phenothiazines to treat chemoresistant neuroblastoma

Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pediatric and rare conditions. In such instances, drug repurpos...

2025-11-13 | MTBLS13246 | MetaboLights
TranscriptomicsTranscription profiling of cultured mouse astrocytes in response to stimulation with CCM (complete cytokine mix: TNF-alpha, IL1-beta and IFN-gamma) at 4hr and 16hr time points
Transcriptional activation of cultured mouse astrocytes in response to stimulation with CCM (complete cytokine mix: TNF-alpha, IL1-beta and IFN-gamma) at 4hr and 16hr time points.
ORGANISM(S): Mus musculus 
2005-12-01 | E-MEXP-321 | biostudies-arrayexpress
ProteomicsPPT1 binding proteins - The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function
Binding of proteins from mouse brain lysates to GFP-PPT1
ORGANISM(S): Mus musculus (Mouse) 
2019-11-08 | PXD006429 | Pride
Gfp-ppt1 Immunoprecipitation Mouse brain 
ProteomicsPhospho-proteome of obese mice brains
This study aims to investigate changes in phospho-proteomic levels of mice brain. The focus of the study is the phospho-proteome because phoshorylation is one of the key post-translational modification, which regulates many biological processes. In particular we wanted to inspect the effects of two ...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-10 | PXD005815 | Pride
Obesity Diet Cns development Mice brains Phospho-proteome 
GenomicsML
NcOEDG Malmo - Lund samples
EGAD00000000039 | EGA
ProteomicsBRCA protein subtype - Molecular Portrait of Breast-Cancer-Derived Cell Lines Reveals Poor Similarity with Tumors
Shotgun MSMS data of breast tumor intrinsic subtypes
ORGANISM(S): Homo sapiens (Human) 
2016-07-08 | PXD000944 | Pride
Shotgun Breast tumor Intrinsic subtypes Orbitrap 
ProteomicsN-glyco db/db mouse kidney - N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models
N-glycosylated proteome of db/db diabetic mice with diabetic nephropathy, additional effect of insulin on db/db mice.
ORGANISM(S): Mus musculus (Mouse) 
2016-12-13 | PXD003349 | Pride
Db/db mice Mass spectrometry N-glycosylation N-glyco capture Insulin Diabetic nephropathy Diabetes 
ProteomicsLiraglutide effect on STZ Mouse Kidney with diabetic nephropathy
The effect of liraglutide on the kidney proteome in the STZ mouse model compared to healthy and STZ diabetic control groups.
ORGANISM(S): Mus musculus (Mouse) 
2019-01-18 | PXD003007 | Pride
Liraglutide Kidney Proteome Stz Shotgun Diabetes nephropathy Label-free 
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