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ProteomicsWidespread hydroxylation of unstructured lysine-rich protein domains by JMJD6
The Jumonji domaining-containing protein JMJD6 is a 2-oxoglutarate dependent dioxygenase that has been implicated in a broad range of biological functions. Cellular studies have implicated the enzyme in chromatin biology, transcription, DNA repair, mRNA splicing and co-transcriptional processing. Al...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-02 | PXD031221 | Pride
Human Lc-msms Hydroxylation Jmjd6 Lysine derivatisation 
ProteomicsKDM3A catalysed formation of hydroxyacetyl-lysine on histone H3K9
Histone modifications, including N-lysine acetylation and methylation, play critical roles in eukaryotic transcription. The addition of acetyl- and methyl-groups and removal of acetyl-groups involves redox neutral reactions, whereas demethylation is O2 dependent, a reaction with potential to enable ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD057969 | Pride
Histone demethylation / hydroxylation / acetylation / 2-oxoglutarate dependent oxygenase / jmjc kdms / demethylases / kdm3a / kdm3b / hypoxia inducible factor / hif prolyl hydroxylases / epigenetics 
ProteomicsFASIL-MS: An Integrated Proteomic and Bioinformatic Workflow to Universally Quantitate In vivo-acetylated Positional Isomers
Dynamic changes in histone post-translational modifications (PTMs) regulate gene transcription leading to fine-tuning of biological processes such as DNA replication and cell cycle progression. Moreover, specific histone modifications constitute docking sites for recruitment of DNA damage repair pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2016-06-16 | PXD003611 | Pride
Ms2-based quantitation Lysine deacetylase inhibitor Histone acetylation Mass spectrometry N-acetoxy-d3-sucinnimide Fasp Protein derivatisation 
ProteomicsPhosphorylation of methyltransferase Set2p and demethylase Jhd1p and its association with histone H3K36 methylation and stress response pathways in Saccharomyces cerevisiae
Histone lysine methylation is a key epigenetic modification that regulates eukaryotic transcription. In Saccharomyces cerevisiae, it is controlled by a reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) en...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-03-07 | PXD029088 | Pride
Epigenetics Demethylase Signalling Histone methylation Yeast Chromatin Methyltransferase 
ProteomicsAn unexpected histone-binding activity for the MIER1 histone deacetylase complex suggests a potential chaperone function.
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails. In addition to the deacetylase subunit, these complexes typically cont...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD040685 | Pride
Methylation Deacetylase Histone 
ProteomicsAn unexpected histone-binding activity for the MIER1 histone deacetylase complex suggests a potential chaperone function.
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails. In addition to the deacetylase subunit, these complexes typically cont...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD036303 | Pride
Methylation Deacetylase Histone 
UnknownHistone demethylase inhibitor KDM5-C70 regulates metabolomic and lipidomic programming during an astrocyte differentiation of rat neural stem cell.
Not available
S-EPMC11825845 | biostudies-literature
UnknownInitial Screening of Poly(ethylene glycol) Amino Ligands for Affinity Purification of Plasmid DNA in Aqueous Two-Phase Systems.
Not available
S-EPMC8619368 | biostudies-literature
UnknownStructure-guided optimisation of <i>N</i>-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α.
Not available
S-EPMC10631261 | biostudies-literature
MetabolomicsControlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture on viral replication is insufficiently understood. Single cell transcriptomics applying vesi...
2025-06-24 | MTBLS12437 | MetaboLights
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