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ProteomicsLysosomal proteomics reveals mechanisms of neuronal apoE4 - 2 associated lysosomal dysfunction
The E4 variant of APOE is the primary risk factor for Alzheimer’s Disease. While APOE is primarily expressed by astrocytes, early AD pathology appears predominantly in neurons, including endosomal abnormalities and mitochondrial dysfunction. Lysosomes are poised at the convergence point between thes...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD044942 | Pride
Lgals3bp Apms Mass spectrometry Apoe 4 Alzheimer’s disease Lysosomes 
ProteomicsLC-MS/MS analysis of soluble lysosomal enzymes
Mucolipidosis III gamma (MLIII) is clinically characterized by onset of first symptoms at an average of 5 years such as stiffness of hands and shoulders, claw hand deformities, scoliosis and progressive destruction of hip joints. The disease is caused by mutations in GNPTG encoding the gamma-subunit...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-07 | PXD007547 | Pride
Mucolipidosis Lysosomal proteomics 
ProteomicsTargeting of non-phosphorylated lysosomal enzymes involves secretion and Lrp1-mediated recapture
Most lysosomal enzymes require mannose 6-phosphate (M6P) residues for efficient receptor-mediated lysosomal targeting. Although the lack of M6P results in missorting and hypersecretion, selected lysosomal enzymes reach normal levels in lysosomes of various cell types suggesting the existence of M6P-...
ORGANISM(S): Mus musculus (Mouse) 
2015-05-01 | PXD001221 | Pride
Low density lipoprotein-related receptor/ lysosomal targeting/ mannose 6-phosphate/ receptor-mediated endocytosis/ sortilin 
ProteomicsProteomic analysis of Trichomonas vaginalis phagolysosome, lysosomal targeting, and unconventional secretion of cysteine peptidases
Lysosomes represent a central degradative compartment of eukaryotes, yet little is known about biogenesis and function of this organelle in parasitic protists. Whereas the mannose-6 phosphate (M6P)-dependent system is dominant for lysosomal targeting in metazoans, oligosaccharide independent sorting...
ORGANISM(S): Trichomonas vaginalis 
2023-07-26 | PXD027545 | Pride
Trichomonas vaginalis Glycosylation Mannose-6-phosphate receptor Phagolysosome Cysteine peptidase Proteome 
ProteomicsDisruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model.
Supporting data for "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model", DOI: T.B.D. Related to Figure 4A and S4A-B. KN43-66 - TMTpro | 4plex | Whole cell proteome - MS3 KN67-72 - TMTpro | 4plex | Enriched Phospho-peptides - MS2 K...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-24 | MSV000090202 | MassIVE
UnknownSpatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons.
Not available
S-EPMC11868546 | biostudies-literature
ProteomicsLYSET/TMEM251 KO cellular and lysosomal proteomes from MIA PaCa-2 cells
Proteome analysis of post-nuclear supernatants (PNS) and enriched lysosomal fractions from LYSET/TMEM251 knockout and control MIA PaCa-2 cells. Lysosomes were loaded with iron nanoparticles (DexoMAG C, Liquids Research). PNS were generated from cell homogenates and used as input to enrich lysosomal...
ORGANISM(S): Homo sapiens (Human) 
2022-09-29 | PXD029659 | Pride
Pns Lysosomes Human Pancreatic cancer 
ProteomicsTranscriptional control of lysosomal homeostasis by the disease-related CLN3 membrane protein
CLN3 is a type II transmembrane protein localized in the late endosomal/lysosomal compartment. A deficiency of CLN3 leads to the development of a certain type of Neuronal Ceroid Lipofuscinosis, a neurodegenerative disorder of childhood caused by aggregation of undegraded material in the lysosomal co...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-13 | PXD004548 | Pride
Mouse Lysosomal storage disease Cerbellar cells 
ProteomicsHuman 293T cells lysosomal osmotic stress response
The goal of this project is to identify changes of the lysosomal surface proteome upon the induction of lysosomal vacuolation. 293T cells stably expressing LAMP1-GFP-TurboID or Lyso-TurboID were treated with a small molecule apilimod or DMSO to trigger lysosomal vacuolation, after which the lysosoma...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD047404 | Pride
Lysosomal vacuolation Streptavidin purification Lysosomal surface proteome Biotinylation 
UnknownLysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction.
Not available
S-EPMC10592882 | biostudies-literature
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