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ProteomicsHuman 293T cells lysosomal osmotic stress response
The goal of this project is to identify changes of the lysosomal surface proteome upon the induction of lysosomal vacuolation. 293T cells stably expressing LAMP1-GFP-TurboID or Lyso-TurboID were treated with a small molecule apilimod or DMSO to trigger lysosomal vacuolation, after which the lysosoma...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD047404 | Pride
Lysosomal vacuolation Streptavidin purification Lysosomal surface proteome Biotinylation 
ProteomicsMultiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health
Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling late-stage maturation of the endo-lysosomal network. Retromer dysfunction, which is linked to neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases, manif...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041323 | Pride
Human Lysoip Neuroglioma Whole cell proteome H4 Retromer Secretome Cell surface proteome Lc-ms/ms 
TranscriptomicsMultiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health
Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling maturation of the endo-lysosomal network. Retromer dysfunction, which is linked to neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases, manifests in com...
ORGANISM(S): Homo sapiens 
2023-04-17 | GSE223292 | GEO
GenomicsMultiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health
Multiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health
PRJNA925533 | ENA
ProteomicsNovel surface functionalized superparamagnetic nanoparticles with engineered cellular uptake as a means for intracellular omics
Superparamagnetic nanoparticles (SPMNPs) are appealing for use in organelle isolation strategies. Yet, this potential remains largely unexplored because thus far research has focused on either physicochemical design or on their application in micron-sized beads. For their use in life sciences, the b...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080688 | MassIVE
UnknownStat3-mediated alterations in lysosomal membrane protein composition.
Not available
S-EPMC5868265 | biostudies-literature
UnknownUrinary proteome profiling for stratifying patients with familial Parkinson's disease.
Not available
S-EPMC7933820 | biostudies-literature
ProteomicsLYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation
Proximity-inducing modalities that co-opt cellular pathways offer new opportunities to regulate oncogenic drivers. Inspired by the success of proximity-based chimeras in both intracellular and extracellular target space, here we describe the development of LYsosome Membrane TArgeting Chimeras (LYMTA...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-01-16 | MSV000096874 | MassIVE
UnknownMulti-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health.
Not available
S-EPMC10227043 | biostudies-literature
ProteomicsThe USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation
The functions of integrins are tightly regulated via multiple mechanisms including trafficking and degradation. Integrins are repeatedly internalized, routed into the endosomal system and either degraded by the lysosome or recycled back to the plasma membrane. The ubiquitin system dictates whether i...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-06 | PXD054760 | Pride
Ubiquitination Usp12/usp46 Escrt Integrin Dub 
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