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GenomicsTranscriptome analysis of Y79 retinoblastoma cells upon Lysyl oxidase propeptide (LOX-PP) overexpression
Transcriptome analysis of Y79 retinoblastoma cells upon Lysyl oxidase propeptide (LOX-PP) overexpression
PRJNA489199 | ENA
TranscriptomicsTranscriptome analysis of Y79 retinoblastoma cells upon Lysyl oxidase propeptide (LOX-PP) overexpression
Lysyl oxidase (LOX) is an copper dependent amine oxidase enzyme involved in cross linking of collagens and elastins. Lysyl oxidase propeptide (LOX-PP) is 18 kDa region cleaved during maturation of LOX and its anti-tumorigenic role were studied in various cancers. The effect of LOX-PP overexpression ...
ORGANISM(S): Homo sapiens 
2019-09-01 | GSE119413 | GEO
GenomicsLysyl oxidase (LOX) inhibition creates vulnerability to ferroptosis by disrupting mitochondrial homeostasis in TNBC
Lysyl oxidase (LOX) inhibition creates vulnerability to ferroptosis by disrupting mitochondrial homeostasis in TNBC
PRJNA1495506 | ENA
TranscriptomicsLOXs in invasive trophoblasts
Human placental development is characterized by invasion of extravillous cytotrophoblasts (EVCTs) into the uterine wall during the first trimester of pregnancy. Peroxisome proliferator-activated receptor gamma (PPARG) plays a major role in placental development, and activation of PPARG by its agonis...
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-28426 | biostudies-arrayexpress
ProteomicsMDA-MB-231 Breast Cancer Bone Tropic vs Parental Hypoxic Secretome Analysis
The project profiled the expression patterns in hypoxia induced secretomes between MDA-MB-231 parental and MDA-MB-231 Bone Tropic (BT) breast cancer cell lines which have been previously generated by Massague and colleagues (Kang et al. Cancer Cell 2003).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080797 | MassIVE
ProteomicsLOX inhibition creates vulnerability to ferroptosis by decoupling glucose metabolism and mitophagy in triple-negative breast cancer
High degree of metabolic heterogeneity and plasticity of triple-negative breast cancer (TNBC) contribute to its aggressiveness and resistance to standard therapies, necessitating identification of novel therapeutic vulnerabilities. Here, we identify non-canonical functions of an ECM remodeler protei...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD071741 | Pride
Mitophagy Tnbc Er-mitochondria contacts (mercs) Dhodh Ferroptosis Lysyl oxidase (lox) Glucose metabolism 
TranscriptomicsEffect of LOX-PP on the gene expression profile of the A673 cell line (Ewing sarcoma)
In this study we show that lysyl oxidase (LOX), an enzyme involved in maintaining structural integrity of the extracellular matrix, is expressed at low levels in Ewing sarcoma cells and primary tumors and is downregulated by the EWS/FLI1 oncoprotein characteristic of these tumors. Using a doxycyclin...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-46407 | biostudies-arrayexpress
OtherLysyl oxidase (LOX) inhibition creates vulnerability to ferroptosis by disrupting mitochondrial homeostasis in TNBC
High degree of metabolic heterogeneity and plasticity of triple-negative breast cancer (TNBC) contributes to its aggressiveness and resistance to standard therapies, necessitating identification of novel therapeutic vulnerabilities. Here, we identify previously unrecognized, non-canonical functions ...
ORGANISM(S): Homo sapiens 
2026-07-19 | GSE338674 | GEO
UnknownAnti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships.
Not available
S-EPMC6937593 | biostudies-literature
TranscriptomicsGATA3 Reprograms Basal Breast Cancer Cells towards a Luminal Subtype and Inhibits Metastases through Suppression of Lysyl Oxidase
The transcription factor GATA3 is essential for luminal cell differentiation during mammary gland development and critical for formation of the luminal subtypes of breast cancer. Ectopic expression of GATA3 promoted global alterations of the transcriptome of basal triple-negative breast cancer cells...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-24249 | biostudies-arrayexpress
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