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ProteomicsLow intrinsic agonism and balanced pathway modulation distinguish an M1 muscarinic receptor positive allosteric modulator lacking cholinergic adverse effects
Positive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (mAChR) have progressed into clinical trials for cognitive disorders, such as Alzheimer’s disease and schizophrenia. This work provides a mechanistic framework for differentiating M1 PAM pharmacology beyond intrinsic a...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD074843 | Pride
Signalling pathways Schizophrenia Cognition Alzheimer's disease M1 muscarinic acetylcholine receptors Allosteric modulation Biased allosterism 
ProteomicsMembrane Proteome Remodeling in Female APP Mice Following Muscarinic Acetylcholine Receptor M1 Modulation Revealed by Peptidisc Enabled DIA-MS
Alzheimer’s disease (AD) is linked to profound dysregulation of membrane-embedded and membrane-associated proteins that govern amyloid processing, synaptic signaling, and neuronal communication. Yet most proteomic analyses prioritize soluble fractions, resulting in systematic underrepresentation of ...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-10 | PXD074065 | Pride
Membrane mimetics Data independent acquisition Mus musculus Membrane proteome profiling App Alzheimer's Peptidisc 
UnknownFlavonoids with M1 muscarinic acetylcholine receptor binding activity.
Not available
S-EPMC6270666 | biostudies-literature
UnknownM1 muscarinic acetylcholine receptor dysfunction in moderate Alzheimer's disease pathology.
Not available
S-EPMC7391992 | biostudies-literature
ProteomicsSlowing prion disease via M1 muscarinic receptors is associated with reduced neuroinflammation and down-regulation of neurodegenerative disease markers
Currently there are no treatments that can slow or halt the progression of dementia’s including Alzheimer’s disease. Here we investigate the possibility that activation of the M1-muscarinic receptor (M1-receptor), which is highly expressed in the brain and that shows pro-cognitive properties, might ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-14 | PXD025561 | Pride
G protein-coupled receptor Alzheimer’s disease Neuroinflammation Warwick_rtp Positive allosteric modulators Transcriptomic Prion disease Proteomic Neurodegeneration Neurodegenerative disease M1 muscarinic acetylcholine receptor 
UnknownThe M1 muscarinic acetylcholine receptor in the crypt stem cell compartment mediates intestinal mucosal growth.
Not available
S-EPMC7437377 | biostudies-literature
UnknownCrystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Not available
S-EPMC4915387 | biostudies-literature
UnknownMolecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.
Not available
S-EPMC3937673 | biostudies-literature
UnknownMechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.
Not available
S-EPMC4246120 | biostudies-literature
UnknownDiscovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists.
Not available
S-EPMC4027492 | biostudies-literature
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