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ProteomicsCombination of Metabolomics, Lipidomics and Molecular Biology to Investigation of Metabolic Disturbance of Short-Term Administration of Emodin
To comprehensively elucidate the possible mechanism of short-term administration of emodin on the metabolic disturbance in vivo, our study utilized both LC/MS and NMR platforms for untargeted metabolomics studies. These analyses aimed to identify potential biomarkers associated with emodin-induced m...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD055000 | Pride
Metabolomics Mouse Lc-ms Lipidomics 
ProteomicsDiscovering new peripheral plasma biomarkers to identify cognitive decline in type 2 diabetes
Type 2 diabetes mellitus (T2DM) is an independent risk factor of Alzheimer's disease (AD), thus, identifying who among the increasing T2DM populations may develop into AD is important for early intervention. By using TMT-labeling coupled high-throughput mass spectrometry, we conducted a comprehensiv...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD027870 | Pride
Type 2 diabetes Mild cognitive impairment Proteomics Cip2a Alzheimer's disease Diagnostic biomarkers 
ProteomicsPlatelet biomarkers identifying mild cognitive impairment in type 2 diabetes patients
Here, we performed platelet proteomics in T2DM patients with MCI (T2DM-MCI) and without MCI (T2DM-nMCI)
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023316 | Pride
Alzheimer's disease  mild cognitive impairment  type 2 diabetes mellitus  peripheral biomarkers  platelet  proteomics  optineurin 
ProteomicsSynechocystis sp. PCC 6803 WT and Δhik33 (sll0698) proteomic research, proteomic data of normal culture conditions.
In this study, by using shotgun LC-MS/MS approach with the Tandem Mass Tag (TMTs) isobaric labelling technique we show that proteins in photosystem, inorganic carbon uptake and CO2 fixation systems are significantly changed in Δhik33 cells compared with WT cells.This is the normal culture condition ...
ORGANISM(S): Synechocystis sp. PCC 6803 
2017-05-19 | PXD005085 | Pride
Synechocystis sp. pcc 6803  hik33 mutant  lc-msms 
ProteomicsAn integrated analysis of protein abundance, transcript level and tissue diversity to reveal developmental regulation of maize
The differentiation and subsequent development of plant tissues or organs are tightly regulated at multiple levels, including the transcriptional, posttranscriptional, translational, and posttranslational levels. Transcriptomes define many of the tissue-specific gene expression patterns in maize, an...
ORGANISM(S): Zea mays (Maize) 
2018-01-02 | PXD008464 | Pride
Tissue-specific proteins Proteome Swath-ms Differentially expressed proteins Transcriptome Zea mays l. 
ProteomicsMass spectrometric analysis of fluorophore labeled albumins
A genetic engineering strategy for editing near-infrared-II fluorophores. The labeled albumin proteins were digested using suspension trapping (STrap) approach with in-house packed glass fiber filters. The LC-MS/MS analysis was performed on a nanoLC-Q Exactive MS system. The protein identification w...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-07 | MSV000087386 | MassIVE
TranscriptomicsDNA methylation profiling in the Carolina Breast Cancer Study
A microarray targeting promoters of cancer-related genes was used to evaluate DNA methylation at 935 CpG sites in 517 invasive breast tumors from the Carolina Breast Cancer Study (CBCS), a population-based study of invasive breast cancer. Concensus clustering using methylation (β) values for the 16...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-51557 | biostudies-arrayexpress
ProteomicsThe NAE1-mediated Neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Cells were lysed with TFA, and precipitated with cold acetone. The precipitates were transferred to E3filters and digestion was performed overnight with trypsin. The peptides were desalted with StageTips, and were analyzed on Eclipse Orbitrap with DIA mode. For MS1, the resolution was set to 120,00...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-27 | MSV000094179 | MassIVE
ProteomicsMass spectrometry-based protein interactome and phosphoproteomics data upon NRDE2 overexpression
The HEK293T cells transiently expressing Flag-tagged empty vector or Flag-NRDE2-WT were lysed in NETN buffer (10 mM Tris-HCl [pH 8.0], 100 mM NaCl, 1 mM EDTA, and 0.5% NP-40) and immunoprecipitated with anti-Flag M2 agarose (M8823; Sigma-Aldrich, MO, USA). After washing four times with the high stri...
ORGANISM(S): Homo Sapiens 
2024-03-31 | PXD051117 |
ProteomicsSARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal pathogen of the ongoing global pandemic of coronavirus disease 2019 (COVID-19). Loss of smell and taste are new identified symptoms of COVID‐19, and both of these are related to cilia dysfunction. However, the pathological me...
ORGANISM(S): Homo Sapiens 
2022-02-23 | PXD031842 |
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