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ProteomicsStreptococcal S protein is a coordinator of cell wall repair and defense against host antimicrobials
Pathogenic bacteria have acquired the ability to resist antibacterial defense mechanisms of the host. Streptococci are common in animal microbiota and include opportunistic pathogens like Group A Streptococcus (GAS) and Streptococcus pneumoniae (pneumococcus). While the conserved streptococcal S pro...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2026-06-08 | PXD055534 | Pride
S-protein Cell wall repair Streptococcus pneumoniae Penicillin-binding protein 
ProteomicsThe Role of c-Jun Signaling in Cytidine Analog-Induced Cell Death in Melanoma
Melanoma stands as an increasingly pressing health concern. Enhanced mitochondrial metabolism has been reported in melanoma cells that survived treatment with traditional therapeutics, including cytidine analogs like gemcitabine (GEM). These findings suggest that chemotherapeutic drugs may play dual...
ORGANISM(S): Homo sapiens (Human) 
2026-10-07 | PXD060382 | Pride
Jnk C-jun Melanoma Apoptosis Chemotherapy Cancer 
ProteomicsLabel-free quantitative proteome of AML CD34+ and mobilized PB CD34+ cells
The label-free quantitative proteome was generated for 42 primary AML patient samples enriched for CD34+ cells (or mononuclear cells in the case of NPMcyt sameples) and as controls 6 mobilized peripheral blood CD34+ cells were included. Furthermore, 6 AML cell lines were included, and also primary m...
ORGANISM(S): Homo sapiens (Human) 
2022-03-15 | PXD030463 | Pride
Acute myeloid leukemia Leukemic stem/progenitor cells 
ProteomicsSARS-CoV-2 Evades immune detection in Alveolar Macrophages
Respiratory infections, like the current pandemic SARS-CoV-2 virus, target the epithelial cells in the respiratory tract. However, alveolar macrophages (AMs) are tissue-resident macrophages located within the alveoli of the lung and they play a key role in the early phases of an immune response to r...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD021685 | Pride
Sars-cov-2 Prm Alveolar macrophages 
ProteomicsLabel-free quantitative proteome of CD34+ or CKIT+ AML cells and mobilized PB CD34+ cells
The label-free quantitative proteome was generated for 30 primary AML patient samples enriched for CD34+ cells or CKIT+ cells in the case of NPMcyt samples. As controls 3 mobilized peripheral blood CD34+ cells were included.
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD030487 | Pride
Acute myeloid leukemia Leukemic stem/progenitor cells 
ProteomicsThe C-terminal domain of periostin is intrinsically disordered and interacts with 143 proteins in an in vitro epidermal model of atopic dermatitis
Human periostin is a 78-91 kDa alternatively spliced protein belonging to the group of matricellular proteins. The protein has been implicated in extracellular matrix remodeling, tumor development, and metastasis, inflammatory diseases like atopic dermatitis, psoriasis, and asthma. The C-terminal ma...
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD040164 | Pride
Heparin-binding protein Extracellular matrix protein Periostin Wound healing Connective tissue Protein‐protein interactions Alternative splicing Intrinsically disordered protein Atopic dermatitis 
ProteomicsThe structures of R124H and R555W TGFBIp suggest a direct role of the mutated residues in the aggregation of TGFBIp in granular corneal dystrophy
Protein aggregation in the outermost layers of the cornea, leading to cloudy vision and in severe cases blindness, is linked to mutations in the extracellular matrix protein, transforming growth factor-β-induced protein (TGFBIp). Among the most frequent disease-causing mutations are R124H and R555W,...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD022976 | Pride
Tgfbip X‐ray crystallography Extracellular matrix protein Lattice corneal dystrophy Granular corneal dystrophy Protein cross‐linking Tgfbi Protein aggregation 
ProteomicsChemical phosphoproteomic approaches reveal substrate specificity of protein phosphatases-1 and -2
The phosphatases PP1 and PP2A are responsible for the majority of dephosphorylation reactions on phosphoserine (pS) and –threonine (pT), and are involved in basically all cellular processes and many related diseases. They are thought to have no appreciable intrinsic substrate specificity, but to gai...
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD012026 | Pride
Co-immunoprecipitation Phosphatase substrates Quantitative phosphoproteomics 
ProteomicsCorneal protome of trangenic TGFBI R124H mouse model
In this study we analysed the proteome of transforming growth factor β-induced protein (TGFBIp) R124H transgenic mouse corneas in an attempt to understand the disease mechanisms leading to the granular corneal dystrophy type 2. The transgenic mouse model was generated by insertion of human TGFBI cDN...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-10-20 | PXD012902 | Pride
Mouse Cornea Lc-ms/ms 
ProteomicsActivity-Guided Proteomic Profiling of Proteasomes - Whole proteome studies
A composition of proteasome complexes in WT yeast, and the changes these complexes undergo upon the deletion of Pre9 (Δα3) or of Sem1 (ΔSem1) based on whole-cell proteomic analysis and to activity-guided proteasome profiling of indicates that the amounts of proteasomal proteins and proteasome intera...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-15 | PXD045047 | Pride
Activity-guided profilling Proteasome 
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