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TranscriptomicsTranscription profiling of yeast expressing mouse major histocompatibility complex class I heavy chain H-2K(b)
To dissect the requirements of membrane protein degradation from the ER, we expressed the mouse major histocompatibility complex class I heavy chain H-2K(b) in yeast. Like other proteins degraded from the ER, unassembled H-2K(b) heavy chains are not transported to the Golgi but are degraded in a pro...
ORGANISM(S): Saccharomyces cerevisiae 
2005-06-28 | E-SMDB-1576 | biostudies-arrayexpress
ProteomicsKinetics of abacavir-induced remodelling of the Major Histocompatibility Complex class I peptide repertoire
Characterisation of the kinetics of abacavir-induced perturbation of the immunopeptidome of the Major Histocompatibility Complex (MHC) class I molecule HLA-B*57:01.
ORGANISM(S): Homo sapiens (Human) 
2021-05-11 | PXD024331 | Pride
Mhc i antigen presentation Drug hypersensitivity Peptide selection Abacavir T cells Human leukocyte antigen (hla) Immunopeptidome Tapasin 
ProteomicsA tissue-based draft map of the murine MHC class I immunopeptidome
The array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the adaptive immune system, very lit...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-19 | MSV000084980 | MassIVE
ProteomicsQuantitative Measurement of the Requirement of Diverse Protein Degradation Pathways in MHC Class I Peptide Presentation
The adaptive immune system distinguishes self from non-self by surveying peptides generated from degradation of intracellular proteins that are loaded onto MHC Class I molecules for display on the cell surface. While early studies reported that the bulk of cell surface MHC Class I complexes require ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-15 | MSV000091285 | MassIVE
TranscriptomicsGene expression microarray analysis on hippocampus of Schnurri-2 knockout and wild-type control mice
Schnurri-2 (Shn-2), an NF-kappa B site-binding protein, tightly binds to the enhancers of major histocompatibility complex (MHC) class I genes and inflammatory cytokines, which have been shown to harbor common variant single nucleotide polymorphisms associated with schizophrenia. Shn-2 knockout mice...
ORGANISM(S): Mus musculus 
2013-08-13 | E-GEOD-41307 | biostudies-arrayexpress
TranscriptomicsExpression data from young and adult mice after over expression of self MHC class l protein in skeletal muscle.
Over expression of MHC Class l protein in skeletal muscle causes myositis. Phenotype after expression in young mice is more severe. We performed gene expression profiling on young and adult mice after over expression of self MHC class l protein in skeletal muscle Muscle from young ( early) , adult ...
ORGANISM(S): Mus musculus 
2009-06-02 | E-GEOD-14997 | biostudies-arrayexpress
ProteomicsIdentification of major histocompatibility complex class I ligands in ovarian adenocarcinoma tumors
BACKGROUND. For developing targeted immunotherapy against ovarian adenocarcinoma, direct identification of peptides presented by major histocompatibility complex class I (HLA I) on the surface of tumor cells can be utilized.AIM. To identify ligands of HLA I of ovarian adenocarcinoma tumors. METHODS....
ORGANISM(S): Homo sapiens (Human) 
2026-04-15 | PXD077095 | Pride
GenomicsMacaca mulatta
Macaque Major Histocompatibility Complex Class I Full-Length Genomic Sequences
PRJNA747987 | ENA
ProteomicsEvidence of focusing the MHC class I immunopeptidome by tapasin
Investigation of the repertoire of peptide ligands of highly similar Major Histocompatibility complex (MHC) class I allomorphs differing in tapasin dependence; HLA-B*44:02 (tapasin dependent), HLA-B*44:05 (tapasin independent) and HLA-B*44:05 W147A mutant (tapasin dependent).
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD054743 | Pride
Hla Tapasin Immunopeptidomics 
TranscriptomicsAltered gene expression in the small intestine of IE-Cpr-null mice
The NADPH-cytochrome P450 reductase (CPR) is essential for the functioning of microsomal cytochrome P450 (P450) monoxygenases. The biological functions of the CPR-dependent enzymes in the intestine are not known, despite the vast knowledge available on the biochemical properties of the various oxyge...
ORGANISM(S): Mus musculus 
2012-04-10 | E-GEOD-35293 | biostudies-arrayexpress
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