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ProteomicsImpact of Age and Sex on Plasma Proteome Changes in Mice upon Radiation Exposure
The aim of this project is to assess the impact that age and sex have as parameters for biomarker discovery in radiation research using high-throughput proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2022-05-10 | PXD015859 | Pride
Plasma Radiation Mus musculus Tmt Sex Tandem-mass tag Mouse Age Orbitrap fusion 
ProteomicsZEB2 protects the heart from ischemic damage
infarct size and subsequent deterioration in function. The identification of factors that enhance cardiac repair by the restoration of the vascular network is, therefore, of great significance. Here, we show that the transcription factor Zinc finger E-box-binding homeobox 2 (ZEB2) is increased in st...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-03-23 | PXD022212 | Pride
Angiogenesis Zeb2 Cardiomyocytes Ischemic injury 
Proteomics(Phospho)-proteomic characterization of longitudinal biopsies from HCC patients treated with sorafenib
Tumor response rates to targeted therapy are generally low. This poses an urgent medical need to identify molecular mechanisms that determine responsiveness, to inform drug development and therapy. Here, we performed a proteomics and phospho-proteomics (p)proteomics analysis on longitudinal tumor bi...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD028593 | Pride
Human Super-silac Sorafenib (phospho)-proteomics ((p)proteomics) Hepatocellular carcinoma (hcc) Biopsies 
Proteomics,MultiomicsPlasma Proteome Profiling Reveals the Effects of Weight Loss on the Apolipoprotein Family and Systemic Inflammation Status
Sustained weight loss is the preferred intervention in a wide range of metabolic conditions, but the effects on an individual´s health state remain ill-defined and controversial. Here, we investigate the plasma proteomes of a cohort of 43 obese individuals that had undergone eight weeks of weight lo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-02 | MSV000080596 | MassIVE
GenomicsMelanoma - Exome sequencing
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry - Exome sequencing
PRJEB15496 | ENA
ProteomicsPlasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery
Obesity-related diseases now affect half of the global population, and bariatric surgery is one of the few interventions with long lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specifi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-09-19 | MSV000084344 | MassIVE
UnknownEffectiveness of methotrexate and leflunomide as corticoid-sparing drugs in patients with polymyalgia rheumatica.
Not available
S-EPMC10978571 | biostudies-literature
ProteomicsProteomic characterization of human hepatocellular carcinoma (HCC) tumor biopsies
We analyzed the proteome of tumor and matched non-tumor biopsies from 51 treatment-naive Hepatocellular carcinoma (HCC) patients by DIA (SWATH). Thereby we aim to find subgroups of patients characterized by specific pathway activation. Furthermore, we aim to find novel factors involved in HCC develo...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD025705 | Pride
Human Swath Biopsies Hcc 
UnknownEffect of person-centred care on antipsychotic drug use in nursing homes (EPCentCare): study protocol for a cluster-randomised controlled trial.
Not available
S-EPMC4464611 | biostudies-literature
ProteomicsDirect identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leukocyte antigens (HLA) on the surface of native tumor tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the mel...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-01-30 | MSV000080517 | MassIVE
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