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TranscriptomicsGene profiling in murine Map3k1 mutant embryonic stem cells
Transcriptional profiling of gene expression of embryonic stem cells from mutant Map3k1 mice in comparison to control EL14 cells. The differential expression of specific genes between the mutant and control groups generated from the microarray will give an idea of the molecular mechanisms regulating...
ORGANISM(S): Mus musculus 
2014-06-01 | E-MTAB-1679 | biostudies-arrayexpress
ProteomicsMAP3K1 proximity labeling LC-MSMS in mouse keratinocytes
MAP3K1 is a 196 kDa protein with a large N-terminal regulatory domain that mediates interactions with a wide array of signaling and regulatory proteins. To profile the interactome, we isolated keratinocytes from transgenic mouse, expressing a Cre-inducible TurboID-tagged MAP3K1 and performed biotin-...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-28 | PXD065967 | Pride
Lc-msms Keratinocytes Mouse Map3k1 
ProteomicsQuinoxaline analog selectively inhibits MAP3K1, blocks IKK and NPM1 phosphorylation, and sensitizes pancreatic cancer to gemcitabine
Mitogen activated protein kinase kinase kinase 1 (MAP3K1), is involved in various cancer signaling networks including the NF-B, JNK, ERK, and p38 pathways. Functioning as a signaling kinase in these oncogenic pathways, MAP3K1 contributes to tumor growth and metastasis. Additionally, higher transcrip...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD055363 | Pride
Npm1 Map3k1 Nf-κb Ikkβ Quinoxaline Pancreatic cancer 
GenomicsThe Role of MAP3K1 in the Development of the Female Reproductive Tracts
The Role of MAP3K1 in the Development of the Female Reproductive Tracts
PRJNA994029 | ENA
ProteomicsOestrogen Activates the MAP3K1 Cascade and -catenin to Promote Granulosa-Like Cell Fate in a Human Testis-Derived Cell Line
: Sex determination triggers the differentiation of the bi-potential gonad into either an ovary or testis. In non-mammalian vertebrates, the presence or absence of oestrogen dictates gonad differ-entiation, while in mammals, this mechanism has been supplanted by the testis determining SRY gene. Exog...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026927 | Pride
Oestrogen Sox9 Map3k1 Beta-catenin 
TranscriptomicsTranscriptional profiling of Th17gene expression in Map3k1 control and mutant mice
Mapks are regulators of T cell proliferative expansion and cell cycle progression. Genetic analysis of Th17 cells in Map3k1ΔKD and control mice will demonstrate whether Mekk1 (encoded by Map3k1) signaling activates Jnks to regulate cell cycle molecules and proliferative expansion. Comparative tra...
ORGANISM(S): Mus musculus 
2016-08-31 | E-MTAB-4499 | biostudies-arrayexpress
TranscriptomicsThe Role of MAP3K1 in the Development of the Female Reproductive Tracts
Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) is a dynamic signaling molecule with myriad cell-type specific functions not yet fully understood. Here we describe a role of MAP3K1 in the development of female reproductive tract (FRT). MAP3K1 kinase domain deficient females (Map3k1ΔKD) exhibit imperfo...
ORGANISM(S): Homo sapiens 
2024-03-22 | GSE237130 | GEO
GenomicsMAP3K1 mutations confer tumor immune heterogeneity in hormone receptor-positive HER2-negative breast cancer
MAP3K1 mutations confer tumor immune heterogeneity in hormone receptor-positive HER2-negative breast cancer
PRJNA1157767 | ENA
TranscriptomicsDeciphering Gene Expression Program of MAP3K1 in Mouse Eyelid Morphogenesis
Embryonic eyelid closure is a critical step of mammalian ocular surface development involving the forward movement and ultimate fusion of the upper and lower eyelids. Although its underlying mechanism of action is not fully understood, a functional mitogen-activated protein kinase kinase kinase 1 (M...
ORGANISM(S): Mus musculus 
2012-09-01 | GSE39240 | GEO
TranscriptomicsMAP3K1 mutations confer tumor immune heterogeneity in hormone receptor-positive HER2-negative breast cancer
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer, the most common type of breast cancer, is facing challenges such as endocrine therapy resistance and distant relapse. Immunotherapy has shown progress in treating triple-negative breast cancer, b...
ORGANISM(S): Mus musculus 
2024-12-20 | GSE276527 | GEO
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