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UnknownLenalidomide Maintenance After Autologous Stem-Cell Transplantation in Newly Diagnosed Multiple Myeloma: A Meta-Analysis.
Not available
S-EPMC5652871 | biostudies-literature
TranscriptomicsGene expression profile of PBMCs after intake of fish oil for seven weeks compared to high oleic sunflower oil
Fish oil supplementation has been shown to alter gene expression of mononuclear cells both in vitro and in vivo. However, little is known about the total transcriptomic profile in healthy subjects after intake of fish oil compared to a control group. The objective was to examine the gene expression ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-48368 | biostudies-arrayexpress
ProteomicsIdentification of BER/SSBR proteins and the DNA glycosylases MPG, UNG2, MYH, NTH1, NEIL1 and NEIL3 in replisomes Batch 3
Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions, but how BER is...
ORGANISM(S): Homo sapiens (Human) 
2024-06-07 | PXD004324 | Pride
Ber Batch 3 Ipond Orbitrap Ssbr Replication Quantification Replisome Label free 
ProteomicsMonitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication, Batch 2
Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions, but how BER is...
ORGANISM(S): Homo sapiens (Human) 
2017-11-23 | PXD004494 | Pride
Ber Ipond Batch 2 Orbitrap Ssbr Replication Quantification Replisome Label free 
ProteomicsMonitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication, Batch 1
Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions, but how BER is...
ORGANISM(S): Homo sapiens (Human) 
2017-11-23 | PXD004288 | Pride
Ber Ipond Batch 1 Orbitrap Ssbr Replication Quantification Replisome Label free 
ProteomicsTargeting PCNA in a subgroup of Multiple Myeloma cells inhibits the glycolysis and pentose phosphate pathway (batch TK9)
PCNA is an essential protein in all cells with multiple well-known function in DNA replication and DNA repair. Recently, PCNA was shown to be involved in regulation of cellular signalling and central carbon metabolism via stabilizing the metabolic enzymes ENO1 and 6PGD. Furthermore, ATX-101, a PCNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-25 | PXD033531 | Pride
Targeting Pentose phosphate pathway Tk Multiple myeloma Cells Glycolysis Mib assay Pcna 
UnknownThe association between urgency level and hospital admission, mortality and resource utilization in three emergency department triage systems: an observational multicenter study.
Not available
S-EPMC12044865 | biostudies-literature
ProteomicsAPIM-peptide targeting PCNA improves cisplatin therapy in a rat muscle-invasive bladder cancer model
High mortality rate of muscle-invasive bladder cancer (MIBC) and complexity of disease demand new multi-targeting treatment strategies. Targeting proliferating cell nuclear antigen (PCNA) with a peptide containing the AlkB homologue 2 PCNA interacting motif (APIM), is shown to impair multiple vital ...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-09-10 | PXD008724 | Pride
Ay-27 Rat Mib Lfq Assay 
ProteomicsPCNA-targeting peptide modifies and increases the response to EGFR/HER2/VEGF inhibition in breast cancer cells
To combine inhibition of EGFR/HER2 and targeting of the cytosolic roles of PCNA using the APIM-peptide, and study the anti-cancer effects of this combinatory therapy in in vitro and in vivo breast cancer models.
ORGANISM(S): Mus musculus (Mouse) 
2020-01-15 | PXD011044 | Pride
Tnbc- triple negative breast cancer Pi3k- the phosphoinositide 3-kinase Her2/erbb2- human epidermal growth factor receptor 2 Signaling pathways Egfr- epidermal growth factor receptor Combination therapy Pcna- proliferating cell nuclear antigen Multi-targeting therapy Pr- progesterone receptor Mapk- mitogen-activated protein kinase Autophagy Vegf- vascular endothelial growth factor Er- estrogen receptor 
ProteomicsSystematic Discovery and Validation of T Cell Targets Directed Against Oncogenic KRAS Mutations
Jaewon Choi, Scott P. Goulding, Brandon P. Conn, Christopher D. McGann, Jared L. Dietze, Jessica Kohler, Divya Lenkala, Antoine Boudot, Daniel A. Rothenberg, Paul J. Turcott, John R. Srouji, Kendra C. Foley, Michael S. Rooney, Marit M. van Buuren, Richard B. Gaynor, Jennifer G. Abelin, Terri A. Addo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-13 | MSV000087987 | MassIVE
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