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Metabolomicsmetabolomics Analysis in Cecal Samples
Targeted LC/MS Metabolomics. Cecal contents were lyophilized overnight and approximately 2.5-5 mg was homogenized in 250 µL of 50% acidified acetonitrile (0.3% formic acid) for targeted LC/MS/MS metabolomics (acylcarnitines, amino acids, organic acids, nucleotides, and CoAs) according to validated, ...
2026-06-19 | MTBLS14783 | MetaboLights
MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
UnknownCost-Effectiveness of Pertuzumab in Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.
Not available
S-EPMC5070553 | biostudies-literature
UnknownTREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Not available
S-EPMC7667762 | biostudies-literature
TranscriptomicsGamma delta T cells isolated from spleen of cold-exposed rats against room-temperature placed control
Wistar male rats were exposed of cold for one day or 14 days. Control group was placed into room temperature. Gamma delta T cells were FACS sorted from spleen.
ORGANISM(S): Rattus norvegicus 
2023-10-30 | E-MTAB-13420 | biostudies-arrayexpress
MetabolomicsTranscript, protein and metabolite temporal dynamics in the CAM plant Agave
Already a proven mechanism for drought sustainability, crassulacean acid metabolism (CAM) is a specialized type of photosynthesis that maximizes water-use efficiency (WUE) via an inverse (compared to C3 and C4 photosynthesis-performing species) day/night pattern of stomatal closure/opening to shift ...
2017-10-13 | MTBLS363 | MetaboLights
ProteomicsDevelopmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium
The clearance of untranslated mRNAs by Argonaute proteins is essential for embryonic development in metazoans. However, it is currently unknown whether a similar process exists in unicellular eukaryotes. The ciliate Paramecium tetraurelia harbors a vast array of Argonaute proteins of the Piwi-clade ...
ORGANISM(S): Paramecium tetraurelia 
2023-05-10 | PXD038984 | Pride
Paramecium tetraurelia Piwi Mrna clearance Untranslated mrna Total protein < 25kda Sirnas 
ProteomicsCombined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes
Weill-Marchesani syndrome (WMS) is characterized by severe short stature, in particular short hands and feet (brachydactyly), joint contractures, tight skin, and heart valve, eye, and skin anomalies. Whereas recessive WMS is caused by mutations in ADAMTS10, ADAMTS17, or LTBP2 (all recessive), domina...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD068317 | Pride
Weill marchesani syndrome Adamts proteases Fibrillin Short stature syndromes Extracellular matrix 
ProteomicsDegradomic identification of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) as an ADAMTS9 and ADAMTS20 substrate
ADAMTS9 and ADAMTS20 are homologous secreted proteases implicated in ECM proteolysis and ciliogenesis, but few relevant substrates of these proteases are currently known. Quantitative N-terminomics comparison of RPE-1 cells lacking ADAMTS9 with parental RPE-1 cells identified transmembrane protease ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036612 | Pride
Mt1-mmp Rpe-1 cells Ciliogenesis Adamts9 Adamts20 Mmp14 Extracellular matrix 
ProteomicsProteolysis of fibrillin-2 microfibrils is essential for normal skeletal development
Analysis of mouse Adamts6 and Adamts10 mutant embryos, lacking these homologous secreted metalloproteases individually and in combination, along with in vitro analysis of microfibrils, measurement of ADAMTS6-fibrillin affinities and N-terminomics determination of ADAMTS6-cleaved sites, demonstrates ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027096 | Pride
Fibrillin Fibronectin Hek293t Adamts6 Extracellular matrix 
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