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ProteomicsNovel epigenetic based differentiation therapy for Acute Myeloid Leukemia
We have identified and characterized two lysine (K) deacetylase inhibitors (DACi), CM-444 and CM-1758. These inhibitors demonstrate the ability to promote myeloid differentiation in all acute myeloid leukemia (AML) subtypes at low, non-cytotoxic doses, setting them apart from other commercially avai...
ORGANISM(S): Homo sapiens (Human) 
2024-06-03 | PXD050623 | Pride
Acetylome Bromodomains Daci Epigenetics Non-histone proteins acetylation Acute myeloid leukemia Differentiation-based therapy 
ProteomicsDLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling
Using stable cell lines, we found that succinylation levels were highly dependent on DLST. Furthermore, PPGL-causing DLST mutations, predicted to alter DLST homo-oligomeric complex structure, caused a significant remodeling of the cellular succinylome. Succinylation is thought to cause major chemica...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD036782 | Pride
Dlst  succinylation  pheochromocytoma  paraganglioma 
ProteomicsTIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells.
Immunotherapies against brain metastases have shown clinical benefits mainly when applied to locally asymptomatic patients. It is currently unclear why responses to this therapy drop in symptomatic brain metastases, since the use of corticoids is not consistently involved. We report here that a subp...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-27 | PXD040436 | Pride
Microenvironment Brain metastasis Immunotherapy 
ProteomicsSelenium stress response of the fruit origin strain Fructobacillus tropaeoli CRL 2034
Quantitative proteomic approach was carried out to give some insights into the mechanism by which Fructobacillus tropaeoli CRL 2034 counteracts Se stress.
ORGANISM(S): Fructobacillus tropaeoli 
2026-01-30 | PXD037769 | Pride
Selenium resistance Proteomics Oxidative stress Selenium metabolism Fructobacillus tropaeoli 
MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
UnknownComparable Clinical and Embryological Outcomes in Luteal and Follicular Phase Controlled Ovarian Hyperstimulation: A Retrospective Cohort Study.
Not available
S-EPMC12496433 | biostudies-literature
UnknownVentilatory support and corticosteroid therapy in SARS-CoV-2.
Not available
S-EPMC8683019 | biostudies-literature
UnknownConduction System Pacing for Cardiac Resynchronization Therapy.
Not available
S-EPMC10672305 | biostudies-literature
UnknownAge-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis
Not available
S-EPMC11607893 | biostudies-literature
UnknownDe Novo Variants in the F-Box Protein FBXO11 in 20 Individuals with a Variable Neurodevelopmental Disorder.
Not available
S-EPMC6080769 | biostudies-literature
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