Sort   by:  
 Page size 
ProteomicsHDX-MS of Human Histidine Rich Glycoprotein (HRG)
Histidine rich glycoprotein (HRG) is a multi-domain plasma glycoprotein, which is implicated in numerous biological processes including immune regulation, angiogenesis, coagulation and fibrinolysis. Despite a diverse role of biological functions, structural investigations into HRG have yielded only ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-11-06 | PXD065786 | Pride
Hrg Hdx-ms 
ProteomicsA Proteolytic Switch: USP5 controls SDE2 function via UBL-directed cleavage
Proteolytic processing is a critical regulatory mechanism in eukaryotic cells, yet the molecular identities and mechanisms underlying these events often remain elusive. Silencing Defective 2 (SDE2) is an essential human protein involved in multiple aspects of genome regulation, including DNA repair,...
ORGANISM(S): Homo sapiens (Human) 
2026-06-25 | PXD072107 | Pride
Hdx-ms Sde2 Usp5 Ubiquitin 
ProteomicsFAF2 enhances unfoldase activity of mammalian p97-UFD1-NPL4 complex enabling rational design of p97
To address how adaptor proteins impact human p97 activity, we here employ in vitro reconstitution and a focused biochemical screen to identify adaptors that enhance unfoldase activity of human p97 in the presence of UFD1-NPL4. Of the adaptors tested, Fas-associated factor 2 (FAF2/UBXD8), a UBX domai...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD073479 | Pride
Faf2 Hdx-ms P97 
ProteomicsHDX-MS of Activators and Inhibitors of PI3Kalpha
Harnessing the potential beneficial effects of kinase signalling through the generation of direct kinase activators remains an underexplored area of drug development. This also applies to the PI 3-kinase (PI3K) signalling pathway which has been extensively targeted by inhibitors for conditions with ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD037721 | Pride
Pi3ka Ucl-1938-tro Hdx-ms P110a 
Sort   by:  
 Page size