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ProteomicsExtracellular vesicles as prognostic biomarkers for Multiple Myeloma - a clinical population-based study
Multiple myeloma (MM) is an incurable hematological malignancy of mature B lymphocytes. In this study patients with MGUS, SMM and MM followed in two hematology departments were enrolled. Extracellular vesicles were isolated from bone marrow (BM) and peripheral blood (PB) followed by mass spectrometr...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD024121 | Pride
Cancer Hematological malignancy Extracellular vesicles Myeloma Human 
ProteomicsE. coli EcAmb278 treated with tetracycline
Drug profiling exeriment to elucidate protein regulation upon treatment of a multi-drug resistant E.coli strain with tetracycline.
ORGANISM(S): Escherichia coli 
2017-01-06 | PXD003641 | Pride
Lc-ms Tetracycline Shotgun E. coli Label free 
ProteomicsHuman Diffuse large B cell lymphoma cell lines
We have analyzed by label free mass spectrometry the whole cells and secreted extracellular vesicles (EVs) proteomes of two different molecular subtypes of DLBCL, germinal center B cell (GCB subtype) and activated B cell (ABC subtype). Cell line: OCI-Ly3 (ABC) O3_2.raw O3_1.raw O2_2.raw O2_1.raw O...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD028267 | Pride
Human Cancer Diffuse large b cell lymphoma cell lines Extra cellular vesicles 
ProteomicsWNK1-specific phosphorylation sites in TBC1D1 and TBC1D4 modulate cell surface expression of GLUT1
Glucose uptake by mammalian cells is a key mechanism to maintain cell and tissue homeostasis and relies mostly on plasma membrane-localized glucose transporter proteins (GLUTs). Two main cellular mechanisms regulate GLUT proteins in the cell: first, expression of GLUT genes is under dynamic transcri...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD016218 | Pride
Human Phosphorylation 
ProteomicsPlasma extracellular vesicle proteome identifies diffuse large B cell lymphoma patients
The aggressive B cell lymphoma diffuse large B cell lymphoma (DLBCL) is a heterogeneous entity that requires more precise monitoring and prognosis molecular tools. Extracellular vesicles that are secreted by all cell types are currently recognized as serving as a proxy for the cell of origin. Utili...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036735 | Pride
Cancer Extracellular vesicles Diagnostic Liquid biopsy Plasma 
ProteomicsHuman, bronchoalveolar lavage, extracellular vesicles
The aim of the project was to explore large extracellular vesicles capacity to seperate non lung cancer from lung cancer cases. A case control study of patients suspected for lung cancer (12 non lung cancer and 12 lung cancers). The raw files are labeled according to clinical status. Small and large...
ORGANISM(S): Homo sapiens (Human) 
2020-12-15 | PXD021988 | Pride
Extracellular vesicles Bronchoalveolar lavage Lung cancer 
ProteomicsBronchoalveolar Lavage proteomics
Mass spectrometry based proteome analysis on an observational prospective cohort consisting of 90 suspected lung cancer cases (suspicious=7, no lung cancer suspicion=47 and lung cancer=36 as diagnosed in 2014) which were followed during two years (suspicious=2, no lung cancer suspicion= 39 and Lung ...
ORGANISM(S): Homo sapiens (Human) 
2017-02-13 | PXD004700 | Pride
Human Lung cancer Bronchoalveolar lavage 
ProteomicsMultiple myeloma-derived extracellular vesicles modulate the bone marrow immune microenvironment
One of the hallmarks of multiple myeloma (MM) is a permissive BM microenvironment. Increasing evidence suggest that cell-to-cell communication between myeloma and immune cells via tumor cell-derived extracellular vesicles (EV) plays a key role in the pathogenesis of MM. Hence, we aimed to explore BM...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-05 | PXD032934 | Pride
Mouse Bone marrow Microenvironment Extracellular vesicles Multiple myeloma 
ProteomicsElucidation of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma
A comprehensive systemic assessment of the proteome changes that occur in prostate cancer (PCa) during the onset and course of the illness may produce results that are clinically significant. Proteins, the main participants in the majority of biological events, are both potential biomarkers and ther...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD043874 | Pride
Intraductal prostate carcinoma Proteomics Cribriform Liquid chromatography mass spectrometry Urinary extracellular vesicles 
ProteomicsProteomics of Extracellular Vesicles from hiPSC-Derived Cardiac Organoids
Human cardiac organoids were derived from hiPSCs using a regimen of small molecules and morphogens. Extracellular vesicles (cardEVs) were subsequently isolated from the conditioned medium via differential centrifugation. Finally, the proteomic cargo of cardEVs was characterized using LC-MS/MS and bi...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD072207 | Pride
Cardiod Extracellular vesicles Human Cardiac organoids 
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