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MetabolomicsComparison of lipidome profiles of Caenorhabditis elegans—results from an inter-laboratory ring trial

Introduction

Lipidomic profiling allows 100s if not 1000s of lipids in a sample to be detected and quantified. Modern lipidomics techniques are ultra-sensitive assays that enable the discovery of novel biomarkers in a variety of fields and provide new insight in mechanistic investigations. D...
2022-02-21 | MTBLS2016 | MetaboLights
MetabolomicsThe Sphingolipidome of the model organism Caenorhabditis elegans
Sphingolipids are important lipids and integral members of membranes, where they form small microdomains called lipid rafts. These rafts are enriched in cholesterol and sphingolipids, which influences biophysical properties. Interestingly, the membranes of the biomedical model organism Caenorhabditi...
2024-04-01 | MTBLS963 | MetaboLights
ProteomicsHuman dental calculus LC-MS/MS
The purpose of this study was to investigate oral microbiome and host proteins in archaeological human dental tissues using a shotgun proteomics approach. The research focuses on dental calculus (mineralized plaque), dentine, a carious lesion, and an alveolar bone abscess from the medieval site of D...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Ovis 
2014-01-29 | PXD000412 | Pride
Human Caries Ltq-orbitrap velos Cementum Maxis uhr-qq-tof Medieval Dentine Dental calculus Cattle Abscess Bone Dental plaque Q-exactive hybrid quadrupole orbitrap Sheep Archaeological Periodontitis 
MetabolomicsLipidFrag: Improving reliability of in silico fragmentation of lipids and application to the Caenorhabditis elegans lipidome
Lipid identification is a major bottleneck in high-throughput lipidomics studies. We combined the in silico fragmentation tool MetFrag with LipidMaps lipid-class specific classifiers which calculate probabilities for lipid class assignments. The LipidFrag approach was then applied to MS/MS spectra o...
2017-03-09 | MTBLS291 | MetaboLights
ProteomicsAncient proteins resolve the evolutionary history of Darwin's South American ungulates
The project aimed to characterize the collagen type I (COL1) sequences from Pleistocene Macrauchenia sp. and Toxodon sp. bone samples, and by comparison with existing COL1 sequences available from genomic sources establish the phylogenetic position of both extinct species. In order to resolve their ...
ORGANISM(S): unidentified Equus Orycteropus afer (Aardvark) Cyclopes didactylus (Silky anteater) (Myrmecophaga didactyla) Hippopotamus amphibius (Hippopotamus) Tapirus terrestris (Lowland tapir) (Brazilian tapir) Mylodon darwinii (Giant ground sloth) 
2015-03-19 | PXD001411 | Pride
Lc-ms/ms Macrauchenia Toxodon Bruker maxis hd De novo collagen sequencing Pleistocene Thermo scientific hybrid quadrupole-orbitrap 
MetabolomicsRhizosphere Microbiome Assembly and Metabolic Reprogramming in Phallus rugulosus Revealed by Multi-Omics Integration
We conducted non-targeted metabolomic analysis on the rhizosphere and non-rhizosphere soils of Phallus rugulosus, using LC-MS to quantify metabolites, and compared the data from both to determine the differences in metabolites between the rhizosphere and non-rhizosphere of Phallus rugulosus.
2026-05-17 | MTBLS14504 | MetaboLights
ProteomicsIdentification of peptides and proteins in insect based feed ingredients using LCMSMS
Identification of peptides and proteins of 18 different insect meal samples derived from the species Hermetia illucens (8), Tenebrio molitor (5), Alphitobius diaperinus (3) and Acheta domesticus (2). Proteins were extracted using two different extraction and solubilization methods. Protein digests w...
ORGANISM(S): Alphitobius Diaperinus (ncbitaxon:27448) Hermetia Illucens (ncbitaxon:343691) Acheta Domesticus (ncbitaxon:6997) Tenebrio Molitor (ncbitaxon:7067) 
2019-05-01 | MSV000083737 | MassIVE
ProteomicsSynthesis of chlorophyll-binding proteins in a fully-segregated ∆ycf54 strain of the cyanobacterium Synechocystis PCC 6803
The MS analysis is part of a wider study into chlorophyll biosynthesis. There is previous evidence, from both pulldown and CN-PAGE/immunoblot analyses that the enzyme Mg-protoporphyrin IX methylester cyclase (Cyc1), which catalyses the formation of the the fifth (E) ring in chlorophyll, associates w...
ORGANISM(S): Synechocystis sp. (strain PCC 6803 / Kazusa) 
2016-04-01 | PXD003149 | Pride
Photosystem ii Protochlorophyllide Chlorophyll Synechocystis 6803 Mg-protoporphyrin ix methylester cyclase Ycf54 
MetabolomicsInhibition of jasmonic acid-isoleucine conjugating enzyme JAR1 shifts the local and systemic leaf signals and metabolic profiles in Arabidopsis

• Jasmonates (JAs)-mediated pathways are central signaling hubs in plant defense responses. However, the identification of mobile and non-mobile signals involved in downstream systemic signaling is still less studied.

• Here, we investigate the role of the jasmonic acid-isoleucine conjugati...

2026-03-31 | MTBLS14117 | MetaboLights
ProteomicsFlow Cytometry Analysis of Circulating Extracellular Vesicle Subtypes from Fresh Body Fluids
Extracellular vesicles (EVs) are released by shedding during different physiological processes and are increasingly thought to be new potential biomarkers. However, the impact of pre-analytical processing phases on the final measurement is not predictable and, for this reason, the translation of bas...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD022807 | Pride
Extracellular vesicles  polychromatic flow cytometry  biomarkers  proteomics  fresh peripheral blood. 
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