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ProteomicsRedox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis
In an endotoxaemic mouse model of sepsis, a tissue-based proteomics approach for biomarker discovery identified long pentraxin 3 (PTX3) as the lead candidate for inflamed myocardium. PTX3 accumulated as an octamer due to disulphide-bond formation in heart, kidney and lung ?common organ dysfunctions ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-11-10 | MSV000081708 | MassIVE
ProteomicsExtracellular Matrix Analysis of Human Varicose Veins
To understand the consequences of venous hypertension, normal and varicose veins were evaluated using proteomics approaches targeting the extracellular matrix.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-17 | MSV000080062 | MassIVE
ProteomicsA proteomics-based assessment of inflammation signatures in endotoxemia
The circulating proteome offers insight into the stage and severity of the immune response. To characterise the release kinetics and cellular source of plasma protein changes, serial samples were obtained from healthy volunteers (n=10, 3 time-points) injected with low-dose endotoxin (LPS) and analys...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-11 | PXD021077 | Pride
Human Lps Aorta Dia Tmt Endotoxemia Plasma Mouse 
ProteomicsRedox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis
In an endotoxaemic mouse model of sepsis, a tissue-based proteomics approach for biomarker discovery identified long pentraxin 3 (PTX3) as the lead candidate for inflamed myocardium. PTX3 accumulated as an octamer due to disulphide-bond formation in heart, kidney and lung ?common organ dysfunctions ...
ORGANISM(S): Mus musculus (Mouse) 
2014-07-01 | PXD001020 | Pride
Biomarkers  host-pathogen interaction  inflammatory response  prognostic markers  protein modification  serum/plasma 
ProteomicsECM characterization of aortas from Adamts5+/+ and Adamts5∆cat AngII-treated mice by LC-MS/MS
Objective - Thoracic aortic aneurysm (TAA), a degenerative disease of the aortic wall, is accompanied by changes in the structure and composition of the aortic extracellular matrix (ECM). The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family has recently been implicated ...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-08 | PXD009410 | Pride
Aneurysm Protease Ascending aorta Extracellular matrix Lc-ms/ms Adamts 
ProteomicsECM characterization in stented porcine coronary arteries LC-MS/MS
Bare-metal (BMS) and drug-eluting stents (DES) were implanted in pig coronary arteries with an overstretch during coronary angioplasty under optical coherence tomography guidance. Arteries subjected to plain old balloon angioplasty (POBA) alone served as controls. Stented/balloon dilated segments we...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2017-11-24 | PXD005726 | Pride
Coronary arteries Neointima Media Pig Lc-ms/ms 
ProteomicsImpaired adipose-neuronal crosstalk in obesity
Label-free LC-MS/MS was used to characterise and quantify the secretory profiles of murine perivascular adipose tissue, canonical white adipose tissue, and brown adipose tissue.
ORGANISM(S): Mus musculus (Mouse) 
2022-11-15 | PXD031271 | Pride
Mouse Adipose tissue Label-free quantification 
ProteomicsLoss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis
miR-33 is an intronic microRNA within the gene encoding the SREBP2 transcription factor. Like its host gene, miR-33 has been shown to be an important regulator of lipid metabolism. Inhibition of miR-33 has been shown to promote cholesterol efflux in macrophages by targeting the cholesterol transport...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-11 | PXD023471 | Pride
Mouse plasma 
ProteomicsExtracellular Matrix Proteomics of Human Heart Failure.
MS analysis of human cardiac samples from left ventricles of patients undergoing cardiac transplantation due to ischaemic heart failure. Analysis of extracellular matrix enriched extracts.
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD024135 | Pride
Ischaemic heart failure Cardiac tissue Lc-msms. Extracellular matrix 
ProteomicsProteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport
Transactive response DNA-binding protein 43 (TDP-43) is a predominantly nuclear, ubiquitously expressed RNA and DNA-binding protein. It recognises and binds to UG repeats and is involved in pre-mRNA splicing, mRNA stability and microRNA metabolism. TDP-43 is essential in early embryonic development ...
ORGANISM(S): Homo sapiens (Human) 
2015-06-29 | PXD001668 | Pride
Intracellular transport Tdp-43 Comparative proteomics Amyotrophic lateral sclerosis Frontotemporal lobar degeneration Ranbp1 
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