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UnknownChange in exhaled nitric oxide during peanut challenge is related to severity of reaction.

Background

Peanut allergy affects 3% of Australian children and has a higher risk of anaphylaxis than most food allergies. Predicting who is likely to develop anaphylaxis is still an inexact science. The fraction of exhaled nitric oxide (FeNO) shows promise as a biomarker involved in peanut ...
S-EPMC7386245 | biostudies-literature
UnknownReproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children.

Background

Ara h2 sIgE serum levels improve the diagnostic accuracy for predicting peanut allergy, but the use of Ara h2 purified protein as a skin prick test (SPT), has not been substantially evaluated. The fraction of exhaled nitric oxide (FeNO) shows promise as a novel biomarker of peanut...
S-EPMC4975907 | biostudies-literature
UnknownEffectiveness of switching from antipsychotic polypharmacy to monotherapy.

Objective

This randomized trial addressed the risks and benefits of staying on antipsychotic polypharmacy or switching to monotherapy.

Method

Adult outpatients with schizophrenia taking two antipsychotics (127 participants across 19 sites) were randomly assigned to stay on polypharmac...
S-EPMC3739691 | biostudies-literature
ProteomicsProteomics Reveals Extracellular Matrix Injury in the Glomeruli and Tubulointerstitium of Kidney Allografts with Early Antibody-Mediated Rejection
Antibody-mediated rejection (AMR) accounts for >50% of kidney allograft losses. AMR is caused by donor-specific antibodies (DSA) against HLA and non-HLA antigens in the glomeruli and the tubulointerstitium, which together with high interferon gamma (IFNɣ) and tumor necrosis factor-alpha (TNFα), trig...
ORGANISM(S): Homo sapiens (Human) 
2020-09-22 | PXD017580 | Pride
Glomeruli Basement membrane Glomerular microvascular endothelial cells Tubulointerstitium Systems biology Hla class-i Antibody-mediated rejection Biopsy Kidney Cathepsins. Laser-capture microdissection Proximal tubular epithelial cells Laminin Galectin-1 Glutathione s-transferase omega-1 Extracellular matrix Cytokines Remodeling Proteomics 
UnknownPrincipal components of heritability from neurocognitive domains differ between families with schizophrenia and control subjects.

Objective

Various measures of neurocognitive function show mean differences among individuals with schizophrenia (SZ), their relatives, and population controls. We use eigenvector transformations that maximize heritability of multiple neurocognitive measures, namely principal components of h...
S-EPMC3576168 | biostudies-literature
UnknownGenetic burden associated with varying degrees of disease severity in endometriosis.
Endometriosis is primarily characterized by the presence of tissue resembling endometrium outside the uterine cavity and is usually diagnosed by laparoscopy. The most commonly used classification of disease, the revised American Fertility Society (rAFS) system to grade endometriosis into different s...
S-EPMC4487449 | biostudies-literature
UnknownAssociation between endometriosis and the interleukin 1A (IL1A) locus.

Study question

Are single-nucleotide polymorphisms (SNPs) at the interleukin 1A (IL1A) gene locus associated with endometriosis risk?

Summary answer

We found evidence for strong association between IL1A SNPs and endometriosis risk.

What is known already

Genetic factors contribu...
S-EPMC4262465 | biostudies-literature
UnknownA mouse model for hemoglobin SC disease recapitulates characteristic human pathologies.

Abstract

Sickle cell disease (SCD) is a common, life-threatening group of disorders caused by missense mutations in the β-globin gene (HBB). Mouse models have helped to elucidate the most common form of SCD (hemoglobin SS [HbSS]; homozygous p.Glu6Val) and develop new therapies. In contrast, ...
S-EPMC12745012 | biostudies-literature
UnknownConvergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples.
Recessive mutations in the phenylalanine hydroxylase (PAH) gene predispose to phenylketonuria (PKU) in conjunction with dietary exposure to phenylalanine. Previous studies have suggested PAH variations could confer risk for schizophrenia, but comprehensive follow-up has not been reported. We analyze...
S-EPMC2738981 | biostudies-literature
UnknownExtracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study.

Background

Antibody-mediated rejection (AMR) accounts for >50% of kidney allograft loss. Donor-specific antibodies (DSA) against HLA and non-HLA antigens in the glomeruli and the tubulointerstitium cause AMR while inflammatory cytokines such as TNFα trigger graft injury. The mechanism...
S-EPMC7608967 | biostudies-literature
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