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ProteomicsPROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors
MD-224 is a PROTAC that induces degradation of the human protein MDM2. However, we have found that it also induces degradation of a subset of nuclear receptors. DIA was performed to assess the overall specificity of MD-224 in 293T cells and the colorectal cancer cell line SNU-C4.
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD066110 | Pride
Dia proteomics Pxr Protac Mdm2 Nuclear receptor Md-224 
UnknownDiscovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression.
Not available
S-EPMC6545112 | biostudies-literature
UnknownPROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors.
Not available
S-EPMC12592710 | biostudies-literature
UnknownThe Efficacy of V. odorata Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis.
Not available
S-EPMC9207380 | biostudies-literature
UnknownNeurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion.
Not available
S-EPMC5123838 | biostudies-literature
UnknownUsing Digital Pathology to Understand Epithelial Characteristics of Benign Breast Disease among Women Undergoing Diagnostic Image-Guided Breast Biopsy.
Not available
S-EPMC7357278 | biostudies-literature
UnknownEfficacy and safety of botulinum toxin for treating motor dysfunction in patients with Parkinson's disease: a systematic review and meta-analysis.
Not available
S-EPMC10277107 | biostudies-literature
UnknownSubclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases.
Not available
S-EPMC8417784 | biostudies-literature
TranscriptomicsMDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA
The oncoprotein MDM2 is widely recognized as the principal negative regulator of p53, thereby controlling the expression of numerous RNA polymerase II (Pol II)-dependent genes involved in cell cycle arrest and apoptosis. Beyond this canonical role, MDM2 also engages in transcriptional regulation ind...
ORGANISM(S): Homo sapiens 
2026-08-06 | GSE333484 | GEO
GenomicsMDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA
The oncoprotein MDM2 is widely recognized as the principal negative regulator of p53, thereby controlling the expression of numerous RNA polymerase II (Pol II)-dependent genes involved in cell cycle arrest and apoptosis. Beyond this canonical role, MDM2 also engages in transcriptional regulation ind...
ORGANISM(S): Homo sapiens 
2026-08-06 | GSE334227 | GEO
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