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TranscriptomicsMKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells.
Though mitogen activated protein kinase kinases (MKK or MEK) 1 and 2 are widely assumed to be functionally redundant some reports indicate they possess distinct biologic activities. To test the hypothesis that MEK1 and MEK2 signaling pathways are interchangeable we used two complementary approaches...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-23930 | biostudies-arrayexpress
ProteomicsSystematic mapping of MEK (MEK1, MEK2) interactomes, in WT, inactive, clinically relevant and functional mutations
This dataset provides a comprehensive proteomic map of the MEK1 and MEK2 interactomes, utilizing two complementary mass spectrometry (MS) approaches to capture both stable and transient protein-protein interactions (PPIs). A total of 8 functional and clinical mutations of MEK1 was used as bait in a...
ORGANISM(S): Homo sapiens (Human) 
2026-07-10 | PXD079313 | Pride
Ap-ms Mapk pathway Proximity dependent labeling Ras/raf/mek/erk Turboid Disease mutations Mek1 Mek2 Hek293t Protein-protein interactions 
GenomicsImpact of Mek1 and Mek2 deletion on the transcriptome of spleen B cell subpopulations
Impact of Mek1 and Mek2 deletion on the transcriptome of spleen B cell subpopulations
PRJNA1213147 | ENA
GenomicsV-ATPase-Driven Lysosomal Activation Orchestrates MEK2-Induced Endothelial Reprogramming
V-ATPase-Driven Lysosomal Activation Orchestrates MEK2-Induced Endothelial Reprogramming
PRJNA1498002 | ENA
UnknownInteraction of tRNA with MEK2 in pancreatic cancer cells.
Not available
S-EPMC4908586 | biostudies-literature
UnknownMek2 is dispensable for mouse growth and development.
Not available
S-EPMC162209 | biostudies-literature
TranscriptomicsImpact of Mek1 and Mek2 deletion on the transcriptome of spleen B cell subpopulations
MEK1 and MEK2, the only known activators of ERK, are attractive therapeutic candidates for autoimmune diseases. The deletion of Mek1 in mouse hematopoietic cells was performed using the Mek1 conditional allele (Map2k1tm1Chrn) and the Vav1-icre deleter mouse line (Commd10Tg(Vav1-icre)A2Kio) in the Me...
ORGANISM(S): Mus musculus 
2026-03-01 | GSE287527 | GEO
UnknownDeletion of MAP2K2/MEK2: a novel mechanism for a RASopathy?
Not available
S-EPMC4480871 | biostudies-literature
UnknownMek1 and Mek2 Functional Redundancy in Erythropoiesis.
Not available
S-EPMC8353236 | biostudies-literature
UnknownEndosomal targeting of MEK2 requires RAF, MEK kinase activity and clathrin-dependent endocytosis.
Not available
S-EPMC2750913 | biostudies-literature
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