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TranscriptomicsTranscription profiling of human CD34+ derived neutrophil progenitors from umbilical cord blood, in response to Mek1 activation
analysis of differential gene expression in CD34+ derived neutrophil progenitors from umbilical cord blood, in response to Mek1 activation
ORGANISM(S): Homo sapiens 
2009-08-14 | E-TABM-754 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human MCF10A cells reveal changes upon expression of activated versions of MEK1 and HRAS
MCF10A cells were then transfected with MEK1(S217S221), HRAS(G12V), and null control vectors; Cells were lysed 24 hours post-transfection with collection of total RNA and protein Experiment Overall Design: Overexpression of Oncogenic protein was confirmed via Western blot
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-12764 | biostudies-arrayexpress
TranscriptomicsMKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells.
Though mitogen activated protein kinase kinases (MKK or MEK) 1 and 2 are widely assumed to be functionally redundant some reports indicate they possess distinct biologic activities. To test the hypothesis that MEK1 and MEK2 signaling pathways are interchangeable we used two complementary approaches...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-23930 | biostudies-arrayexpress
ProteomicsCXMS BS3 Ras/BRAF/MEK/1433 complex
RAF-family kinases are activated by recruitment to the plasma membrane by GTP-bound RAS, where they initiate signaling through the MAP kinase cascade. Here we crosslinked (BS3), digested (trypsin), and analyzed via LC-MS/MS KRAS (human, residues 1-169) bound to intact BRAF (human) in an autoinhibit...
ORGANISM(S): Spodoptera frugiperda Homo sapiens (Human) 
2023-10-24 | PXD042584 | Pride
Cxms Human Braf Mek1 14-3-3 Sf9 Kras 
ProteomicsSystematic mapping of MEK (MEK1, MEK2) interactomes, in WT, inactive, clinically relevant and functional mutations
This dataset provides a comprehensive proteomic map of the MEK1 and MEK2 interactomes, utilizing two complementary mass spectrometry (MS) approaches to capture both stable and transient protein-protein interactions (PPIs). A total of 8 functional and clinical mutations of MEK1 was used as bait in a...
ORGANISM(S): Homo sapiens (Human) 
2026-07-10 | PXD079313 | Pride
Ap-ms Mapk pathway Proximity dependent labeling Ras/raf/mek/erk Turboid Disease mutations Mek1 Mek2 Hek293t Protein-protein interactions 
TranscriptomicsExpression Data from 22 human pancreatic cancer cell lines grown in triplicates +/- MEK inhibitor CI-1040
Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. We used microarrays to find gene expression patterns associated with drug response and also identified genes regulated by the MAP kinase pathway 22 pancreatic cell l...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-45757 | biostudies-arrayexpress
GenomicsTranscriptomic profile of polarized WT or Mek1/2_tKO CD4+ T cells
Transcriptomic profile of polarized WT or Mek1/2_tKO CD4+ T cells
PRJNA1273919 | ENA
TranscriptomicsGene expression changes in primary Sertoli cells treated with MEK1/2 inhibitor
To investigate the gene expression regualted by MEK1/2-ERK1/2 signaling in Sertoli cells, we cultured primary Seroli cells and treated bFGF and PD0325901, which are activator and inhibitor of the signaling, respectively. Isolated primary Sertoli cells were incubated with 20ng bFGF, 10uM PD0325901 o...
ORGANISM(S): Mus musculus 
2014-02-01 | E-GEOD-41645 | biostudies-arrayexpress
TranscriptomicsExpression Data from 24 orthotopic tumors grown in the pancreas of mice +/- MEK inhibitor PD0325901
Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. We used microarrays to find gene expression patterns associated with drug response and also identified genes regulated by the MAP kinase pathway 6 pancreatic cell li...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-45758 | biostudies-arrayexpress
GenomicsMEK1/2 inhibitors unlock the constrained interferon response in macrophages through IRF1 signaling
MEK1/2 inhibitors unlock the constrained interferon response in macrophages through IRF1 signaling
PRJNA508969 | ENA
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