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ProteomicsA distal activin-responsive super-enhancer regulates Fshb transcription and gonadotrope differentiation
A large “gene desert” located far upstream from Fshb and Kcna4 contains several gonadotrope-specific accessible chromatin sites which, in chromatin conformation capture (3C), were seen to make distinct contacts with both genes. The region displays several features of a super-enhancer and both genes ...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-27 | PXD072033 | Pride
Activin Fsh Gonadotrope differentiation 
ProteomicsThe peptide repertoire of HLA-B27 includes ligands with lysine at P2 anchor position
The HLA-B*27 peptidome has drawn significant attention due to the genetic association between some of the HLA-B*27 alleles and the inflammatory rheumatic disease ankylosing spondylitis (AS). The role of HLA-B*27 in this condition is not known yet. This study aims to expand the known limits of the HL...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-04-10 | PXD007756 | Pride
Hla-b*27 Transgenic rats Peptidome Immunopeptidome Ankylosing spondylitis Human leukocytes antigen 
ProteomicsHLA B-27 rats peptidome - The HLA-B27 peptidome in vivo in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of ERAP1 deletion
HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding to MHC-I molecules. ERAP1 shows genetic epist...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-02-13 | PXD005502 | Pride
Transgenic rats Hla-b27 Peptidome Ankylosing spondylitis Human leukocytes antigen 
ProteomicsMapping the soluble human leukocyte antigen peptidome of pleural effusions reveals lung and tumor-associated antigens
Soluble HLA (sHLA) molecules released to the plasma, carry their original peptide cargo and provide insight into the protein synthesis and degradation schemes of their source cells and tissues. Other body fluids, such as pleural effusions, may also contain sHLA-peptide complexes, and can potentially...
ORGANISM(S): Homo sapiens (Human) 
2022-05-25 | PXD027766 | Pride
Tumor antigens Immunopeptisome Pleural effusion Cancer/testis antigens Hla peptidome Lung cancer Lc-ms/ms 
ProteomicsDifferential modulation of the phosphoproteome by the MAP Kinases isoforms p38α and p38β
The stress-activated p38 mitogen activated protein kinases (MAPK) mediate responses to osmotic shock, radiation, immune stimuli, inflammatory cues, and many other stresses. These kinases are activated rapidly, within seconds of stress induction, yet, their continuous activation, as commonly happens ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD038389 | Pride
Phosphoproteome Silac Stress response P38 mapk Signaling 
ProteomicsA-to-I mRNA editing enables bacteria to produce two protein versions from a single gene and affects bacterial growth
Adenosine-to-inosine (A-to-I) mRNA editing can affect the sequence and function of translated proteins because the ribosome reads inosine (I) as guanosine (G). Previously, we discovered that A-to-I mRNA editing occurs in Escherichia coli. However, the prevalence of A-to-I mRNA editing across bacteri...
ORGANISM(S): Acinetobacter baylyi 
2025-07-21 | PXD051887 | Pride
Adenosine-to-inosine (a-to-i) mrna editing  gammaproteobacteria 
ProteomicsA-to-I mRNA editing controls disulfide bond formation and the toxicity of the HokB toxin in bacteria
Protein disulfide bonds between cysteine residues serve a prominent role in bacterial protein function, virulence, and viability. Adenosine-to-inosine (A-to-I) mRNA editing changes the genetic information at the RNA level. Previously, we discovered that A-to-I mRNA editing occurs in bacteria (Escher...
ORGANISM(S): Escherichia coli 
2025-07-14 | PXD051162 | Pride
Tada Adenosine-to-inosine rna editing Toxin-antitoxin Disulfide bond Hokb Bacteria Dsba 
ProteomicsHLA-B27 interferes with TGF-/activin signaling in Drosophila and rat transgenic models, resulting in pathogenic consequences relevant for spondyloarthritis.
Background The striking association of HLA-B27 with spondyloarthritis (SpA) has been known for 50 years. However, its pathophysiological significance remains incompletely understood. In the HLA-B27/human-β2 microglobulin (hβ2m) transgenic rat (B27 rat) that spontaneously develops inflammatory pheno...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-10-17 | PXD047119 | Pride
Hla peptidome Spondyloarthritis  bmp/tgfβ pathway  hla-b27  cd4+ t cells  rat  drosophila 
ProteomicsThe effect of interferons on presentation of defective ribosome products as HLA peptides
The class I major histocompatibility complex (MHC) bound peptides, produced from immature proteins that are degraded rapidly are called defective ribosome products (DRiPs). Such DRiPs are possibly involved with early alerting of the immune system about impeding infections, thus bringing about faster...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-25 | MSV000096209 | MassIVE
Proteomics,MultiomicsHLA peptides (LC-MSMS) induced by Decitabine in Glioblastoma cell lines
Treatment of cancer cells with anti-cancer drugs often fails to achieve complete remission. Yet, such drug treatments may induce alteration in the tumor’s gene expression patterns, including those of Cancer/Testis Antigens (CTA). The degradation products of such antigens can be presented as HLA pept...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080843 | MassIVE
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