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ProteomicsQuantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-κB, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-stimulated Macrophages
There is a present need to develop alternative biotherapeutic drugs to mitigate the exacerbated inflammatory immune responses characteristic of sepsis. The potent endotoxin lipopolysaccharide (LPS), a major component of Gram-negative bacterial outer membrane, activates the immune system via Toll-lik...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD065520 | Pride
Tmt-labeling  proteomics  fasciola hepatica  fh15  tlr  nf-κb  inos  cd36  lck  lps  macrophages  sepsis 
ProteomicsModulation of Intracellular Pathways of HIV-1 infected Macrophages exposed to Sigma-1 Receptor Antagonist (BD1047) prior to Cocaine and its Role in Cathepsin B Secretion revealed by Quantitative Proteomics
HIV-1 infects monocytes derived macrophages (MDM), that migrate into the brain, and secrete neurotoxic molecules, including cathepsin B (CATB). Cocaine potentiates CATB secretion. Pretreatment with BD1047, a sigma-1 receptor antagonist, before cocaine exposure, reduces infection, CATB secretion, and...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052318 | Pride
Monocyte-derived macrophages (mdm) Bd1047 Human immunodeficiency virus (hiv) Cocaine 
ProteomicsDecreased CSTB, RAGE and Axl receptor is associated with Zika infection in the human placenta
Zika virus (ZIKV) compromises the placental integrity infecting the fetus. However, the mechanisms associated with ZIKV penetration into the placenta leading to fetal infection, are unknown. Cystatin B (CSTB), the receptor for advanced glycation end products (RAGE), and tyrosine-protein kinase recep...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037388 | Pride
Hofbauer cells Trophoblasts Rage Human placenta Axl Cstb Zika virus Quantitative proteomics tmt 
ProteomicsProtein and cytokine profiles associated with COVID-19 disease severity in Puerto Rico
Viral strains, age, and host factors including genetics and proteins are associated with variable immune responses against SARS-CoV-2 and disease severity. We hypothesized that unique proteins/pathways are associated with COVID-19 disease severity in Puerto Rican Hispanics. A total of 121 men and wo...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD046103 | Pride
Covid-19 Proteomics Plasma Sars-cov-2 Cahderin-13 Puerto rico 
ProteomicsQuantitative proteomics reveal that CB2R agonist JWH-133 downregulates NF-κB activation, oxidative stress, and lysosomal exocytosis from HIV-infected macrophages
HIV-associated neurocognitive disorders (HAND) affect 15-55% of HIV-positive patients, with no therapy. HIV-infected monocyte-derived macrophages (MDM) invade the brain of these individuals, promoting neurotoxicity. We demonstrated increased expression of cathepsin B (CATB), a lysosomal protease, in...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048464 | Pride
Proteomics Human Macrophages Neurotoxicity Oxidative stress Hiv Hand Cb2r Cathepsin b 
ProteomicsSCAMP3-Driven Regulation of ERK1/2 and Autophagy Phosphoproteomics Signatures in Triple-Negative Breast Cancer
Despite the promise of ERK1/2 pathway inhibitors, their efficacy is often limited by feedback mechanisms and pathway adaptability, emphasizing the need to identify co-regulatory proteins that modulate ERK1/2 signaling. Previously, we identified secretory carrier membrane protein 3 (SCAMP3) as a key ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD064784 | Pride
Proteomics Scamp3  triple negative breast cancer  erk1/2  autophagy  akt/mtor 
ProteomicsCannabinoid Receptor Type 2 Agonist JWH-133 Stimulates Antiviral Factors and Decreases Proviral, Inflammatory, and Neurotoxic Proteins in HIV-Infected Macrophage Secretome
Although antiviral therapy has improved quality of life, around 50% of people with HIV (PWH) experience neurodegeneration and cognitive decline. This is prompted in part by migration of HIV-infected monocyte-derived macrophages (MDM) to the brain, leading to neuronal death. Previous studies in our l...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD069890 | Pride
Hiv-associated neurocognitive disorders  cb2r  jwh-133  secretome  lc/ms/ms  tmt  proteomics 
ProteomicsProteomic Insights into Extinction Memory Deficits in Stress-Susceptible Female Rats
Stress exposure can disrupt fear extinction, which is a hallmark of some stress-related disorders. The underlying molecular mechanisms of impaired extinction, especially in females, remain poorly understood. In this study, we investigated proteomics changes in the infralimbic cortex, a region critic...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-09 | PXD069169 | Pride
Tau protein Neurogranin Single prolonged stress Quantitative proteomics Fear extinction Infralimbic cortex Stress susceptibility 
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