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TranscriptomicsCyclin D1 Transgenic Mice with Bim-deficient B-cells
Expression analysis from a genetically engineered mouse model of mantle cell lymphoma (MCL) Gene expression was measured in fourteen mice that overexpress cyclin D1 and delete Bim in their B cells and that were stimulated with sheep red blood cells (SRBC) and irradiation (I), pristane (P) or only SR...
ORGANISM(S): Mus musculus 
2014-02-05 | E-GEOD-52214 | biostudies-arrayexpress
ProteomicsIL7R mutational activation can initiate Ph-like and PAX5 P80R precursor B-cell acute lymphoblastic leukemia
Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R, expressed at physiological level...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD017147 | Pride
Acute lymphoblastic leukemia B cells 
ProteomicsNaturally processed flucloxacillin haptenated HLA ligands
This study has demonstrated that natural flucloxacillin haptenated HLA-B*57:01 ligands arepresented by antigen presenting cells through multiple pathways. Identification of such epitopes will help to define the chemical signals responsible for drug-induced immunological disease.
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD020137 | Pride
Dili Hla-b*57:01 Drug hypersensitivity Flucloxacillin 
TranscriptomicsConvergent Sense/Antisense Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability
Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-dependent cytidine deamination of single stranded DNA targets. While largely specific for immunglob...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-62296 | biostudies-arrayexpress
UnknownGenetic analysis of three wild Eurasian eagle-owl subspecies, B. b. kiautschensis, B. b. ussuriensis, and B. b. tibetanus, in Chinese populations.
Not available
S-EPMC7717702 | biostudies-literature
ProteomicsSerological paroteomic biomarkers for monitoring liver fibrosis regression in on-treatment hepatities b patients
Paired serological proteomes from CHB patients undergoing short-term and long-term anti-viral treatment were profiled using PRM-based proteomics technology.The serological proteomic landscapes following AVT were systematically analyzed and compared between fibrosis regressors and non-regressors.
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD063833 | Pride
Hepatitis b plasma prm-ms 
ProteomicsProteomic analyses of plasma-derived exosomes in IgG4-RD and its potential role in B cell differentiation and tissue damage
Objective: This study aimed to investigate plasma exosome profiling of IgG4-RD and its potential role in B cell differentiation and tissue damage. Methods: One hundred untreated IgG4-RD patients and 135 sex, age matched healthy controls (HCs) were enrolled in this study. A combination of liquid chro...
ORGANISM(S): Homo Sapiens 
2020-09-14 | PXD021441 |
ProteomicsSerological paroteomic biomarkers for monitoring liver fibrosis regression in on-treatment hepatities b patients
Paired serological proteomes from CHB patients undergoing short-term and long-term anti-viral treatment were profiled using 4D-DIA-based proteomics technology.The serological proteomic landscapes following AVT were systematically analyzed and compared between fibrosis regressors and non-regressors.
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD059174 | Pride
Anti-viral treatment Hepatitis b Serum 
ProteomicsEffect of hypoxia and treatment with cyclosporine A on chemotaxis of RAMOS B cells
Background: Hypoxia is a potent molecular signal for cellular metabolism, mitochondrial function, and migration. Conditions of low oxygen tension trigger regulatory cascades mediated via the highly conserved HIF-1 α post-translational modification system. In the adaptive immune response, B cells (Bc...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037004 | Pride
Cyclosporine Hypoxia Hif1a Immunosuppressant B cells Cxcl12 
TranscriptomicsMurine germinal center and naive B cells
Gene expressions of murine germinal center and naive B cells on Affymetrix platform The experiment include 3 d14 GC B1-8, 3 d14 GC V23 and 4 NaM-CM-/ve samples
ORGANISM(S): Mus musculus 
2013-03-06 | E-GEOD-44260 | biostudies-arrayexpress
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