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TranscriptomicsTranscription profiling of human renal proximal tubular cell line HK-2 treated with Cyclosporine A timecourse 0, 12, 48 hours
Effect of 4.2 micromolar Cyclosporine A on human renal proximal tubular cell line HK-2 over 48 hours
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1403 | biostudies-arrayexpress
TranscriptomicsCyclosporine on fibroblast
To elucidate the gene profile of anti-fibroproliferative effects of cyclosporine, we added TGF-b and/or CsA to MRC5 (fetal human lung fibroblast) cell line. After 24 hours serum starvation, fibroblasts were treated with 3 ng/ml TGF-β1 and were treated with or without 2μg/ml Cyclosporine and effects ...
ORGANISM(S): Homo sapiens 
2010-11-09 | E-GEOD-25200 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skin samples from atopic dermatitis patients before and after treatment with cyclosporine A
After 2 and 12 weeks of treatment, we observed significant reductions of 51% and 72%, respectively, in SCORAD scores. Clinical improvements were associated with significant gene expression changes in lesional but also nonlesional skin, particularly reductions in levels of TH2-, TH22-, and some TH17-...
ORGANISM(S): Homo sapiens 
2014-06-17 | E-GEOD-58558 | biostudies-arrayexpress
TranscriptomicsActivating CD8 T cell clones via the T cell receptor complex in the absence and presence of cyclosporine A
Comparison of a cyclosporine-resistant murine CD8 T cell clone to a cyclosporine-sensitive murine T cell clone during activation (CSA = Cyclosporine A) Chronic allograft rejection is the leading cause of morbidity/mortality in solid organ and bone marrow transplant patients. It occurs in the settin...
ORGANISM(S): Mus musculus 
2014-04-14 | E-GEOD-46122 | biostudies-arrayexpress
ProteomicsRat Kidney MS analysis with dehydration and cyclosporine treatment
Background- CINAC-patients can be identified by the recently discovered renal proximal tubular cell lysosomal lesions which are also observed in patients experiencing calcineurin inhibitor (CNI) nephrotoxicity, suggesting that CINAC is a toxin-induced nephropathy. An alternative hypothesis advocates...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-11-14 | PXD038062 | Pride
Kidney ms dehydration cyclosporine 
TranscriptomicsDe novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function
Background: Despite significant improvements in short-term kidney transplant survival, comparable increases in 5 and 10-year outcomes have not been achieved. Chronic allograft nephropathy (CAN) is a major cause of late graft loss. Toxic nephropathy and inadequate long-term immunosuppression are poss...
ORGANISM(S): Homo sapiens 
2004-09-23 | E-GEOD-1743 | biostudies-arrayexpress
ProteomicsComparing nephrotoxicity of the calcineurin inhibitors, cyclosporine A and tacrolimus, identifies their differential effects within the renal compartments
Chronic calcineurin inhibitor (CNI) nephrotoxicity is a major drawback in current immunosuppressive regimens. Pathology includes vascular and tubulointerstitial alterations. Although still commonly in use, cyclosporine A (CsA) is increasingly exchanged for tacrolimus (Tac) for a more favorable clini...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-07-25 | PXD038546 | Pride
Kidney Calcineurin Cyclosporine a Nephrotoxicity Rat Tacrolimus Phosphoproteome 
GenomicA Phase I/II Trial of Sirolimus (Rapamune®) and Cyclosporine in Patients with Refractory Aplastic Anemia

The most successful treatment for aplastic anemia is bone marrow transplantation. However, few patients are eligible for this procedure. For others, treatment usually consists of immunosuppressive agents, such as antithymocyte globulin (ATG) and cyclosporine. Unfortunately, even with immunosuppre...

phs000695 | dbGaP
ProteomicsEffect of hypoxia and treatment with cyclosporine A on chemotaxis of RAMOS B cells
Background: Hypoxia is a potent molecular signal for cellular metabolism, mitochondrial function, and migration. Conditions of low oxygen tension trigger regulatory cascades mediated via the highly conserved HIF-1 α post-translational modification system. In the adaptive immune response, B cells (Bc...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037004 | Pride
Cyclosporine Hypoxia Hif1a Immunosuppressant B cells Cxcl12 
TranscriptomicsCyclosporine on fibroblast
To elucidate the gene profile of anti-fibroproliferative effects of cyclosporine, we added TGF-b and/or CsA to MRC5 (fetal human lung fibroblast) cell line. After 24 hours serum starvation, fibroblasts were treated with 3 ng/ml TGF-β1 and were treated with or without 2μg/ml Cyclosporine and effects ...
ORGANISM(S): Homo sapiens 
2010-11-09 | GSE25200 | GEO
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