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TranscriptomicsComparative Transcriptional Profiling of human Merkel cells and Merkel Cell Carcinoma
Merkel cell carcinoma is supposed to be derived from Merkel cells after infection by Merkel cell polyomavirus (MCV) and other poorly known events. A transcriptional profiling with cDNA microarrays was performed on cells from MCV+ Merkel cell carcinomas and isolated normal Merkel cells. This microarr...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-50434 | biostudies-arrayexpress
TranscriptomicsCellular Transcriptional Responses to Merkel cell polyomavirus T antigens
Merkel cell polyomavirus (MCV) is clonally integrated in over 80% of Merkel cell carcinomas and mediates tumor development through the expression of viral oncoproteins large T (LT) and small T antigens (sT). Viral integration is associated with signature mutations in the T antigen locus that result ...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-68503 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of Merkel cell carcinoma (MCC) tumors, small cell lung cancer (SCLC) tumors, and MCC cell lines
When using cell lines to study cancer, phenotypic similarity to the original tumor is paramount. Yet, little has been done to characterize how closely Merkel cell carcinoma (MCC) cell lines model native tumors. To determine their similarity to MCC tumor samples, we characterized MCC cell lines via g...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-50451 | biostudies-arrayexpress
ProteomicsProteomic analysis of extracellular vesicles derived from Merkel cell carcinoma cell lines
Exosomes constitute an evolutionary conserved mechanism of intercellular signaling. Their importance are gaining increasing such as prognostic and diagnostic markers, and potential therapeutic tool. Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a poor prognosis. There are not...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080262 | MassIVE
ProteomicsProteome analysis of Merkel cell carcinoma cell lines using SILAC
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of the skin with growing incidence. In research immortalized cell lines are used for in vitro experiments in order to better understand the biology of this malignant disease.
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD008181 | Pride
Merkel cell Silac Carcinoma 
GenomicsMerkel cell polyomavirus
APOBEC3s mutate Merkel Cell Polyomavirusl genome
PRJDB11225 | ENA
TranscriptomicsDistinct gene expression profiles of viral- and non-viral associated Merkel cell carcinoma revealed by transcriptome analysis
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumor with high mortality rates. Merkel cell polyomavirus (MCPyV), identified in the majority of MCC, may drive tumorigenesis via viral T antigens. However, mechanisms underlying pathogenesis in MCPyV-negative MCC remain poorly ...
ORGANISM(S): Homo sapiens 
2012-10-18 | E-GEOD-39612 | biostudies-arrayexpress
ProteomicsProteomic analysis of extracellular vesicles derived from Merkel cell carcinoma cell lines
Exosomes constitute an evolutionary conserved mechanism of intercellular signaling. Their importance are gaining increasing such as prognostic and diagnostic markers, and potential therapeutic tool. Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a poor prognosis. There are not...
ORGANISM(S): Homo sapiens (Human) 
2016-08-08 | PXD004198 | Pride
Polyomavirus Cancer Exosome Proteomics Merkel cell carcinoma 
ProteomicsPiwil-2 is associated with advanced tumor stage and poor outcome in Merkel cell carcinomas
Merkel cell carcinomas (MCCs) are rare, highly aggressive skin cancers with poor outcome due to early lymphatic tumor spread and frequent recurrences. MCCs mostly occur in the head and neck and are mainly caused by an infection with the Merkel cell polyomavirus (MCPyV). Increasing evidence suggests ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD059625 | Pride
Sox-2 Mcpyv Merkel cell carcinoma Piwil-2 Pirna 
TranscriptomicsmicroRNA expression patterns related to merkel cell polyomavirus infection and clinical outcomes in human merkel cell carcinoma
We performed miRNA expression profiling in a series of human Merkel Cell carcinoma samples using a microarray approach. Significant differentially expressed miRNAs among groups were identified using SAM analysis. Agilent microarray platform containing 723 human miRNAs was used to determine miRNA ex...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-43699 | biostudies-arrayexpress
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