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ProteomicsiTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics
Mertins P, Udeshi ND, Clauser KR, Mani DR, Patel J, Ong, SE, Jaffe JD, Carr SA. Mol Cell Proteomics 2012, mcp.M111.014423. doi:10.1074/mcp.M111.014423. Tranche_hash:5cHw5Rj36vYNshNpy8k4nojtPyW27N/FHcImna3+zw4QV6KIlLOg3i6zesWBdWkEX608MEgdxWuVyKvvdOgB9BAanesAAAAAAACEzw==
2013-11-20 | MSV000078495 | MassIVE
ProteomicsDirect-to-biology: Accelerated E3 ligase modulator discovery
Quatintative analysis of the effects of the E14 compound on the proteome of MM.1S cells.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046752 | Pride
Mm.1s Degraders Multiple myeloma 
ProteomicsIntegrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA. Nat Methods 2013, 10, 634-7. doi: 10.1038/nmeth.2518.
2013-12-10 | MSV000078509 | MassIVE
ProteomicsComprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories
In this study, we evaluated the feasibility of proteomics and phosphoproteomics on formalin-fixed paraffin-embedded (FFPE) lung tissue for protein extraction protocols, quantification methods, pre-analytics, and sample size. First, we compared three protocols for the extraction of proteins from FFPE...
ORGANISM(S): Homo sapiens (Human) 
2021-05-05 | PXD024800 | Pride
Proteomics Ffpe Nsclc 
ProteomicsMass spectrometry-based proteomics reveals potential roles of NEK9 and MAP2K4 in resistance to PI3K inhibitors in triple negative breast cancer

Filip Mundt, Sandeep Rajput, Shunqiang Li, Kelly Ruggles, Arshag D. Mooradian, Philipp Mertins, Michael A. Gillette, Karsten Krug, et al., Cancer Res. 2018 May 15;78(10):2732-2746. doi: 10.1158/0008-5472.CAN-17-1990.

Activation of phosphoinositide 3-kinase (PI3K) signaling is frequently obs...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-19 | MSV000083050 | MassIVE
ProteomicsIon Mobility-Tandem Mass Spectrometry of Mucin-type O-Glycans
The dense O-glycosylation of mucins plays an important role in the defensive properties of the mucus hydrogel. Aberrant glycosylation is often correlated with inflammation and pathology such as COPD, cancer, and Crohn’s disease. The inherent complexity of glycans and the diversity in the O-core stru...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2024-03-19 | PXD050530 | Pride
O-glycans  ion mobility  mass spectrometry  isomeric separation  dda  proteome 
ProteomicsChanges in Sputum Viscoelastic Properties and Airway Inflammation in Primary Ciliary Dyskinesia are Comparable to Cystic Fibrosis on Elexacaftor/Tezacaftor/Ivacaftor Therapy
ivacaftor (ETI) therapy. Methods: We measured and compared sputum rheology, inflammation markers and the proteome in 42 clinically stable adolescent and adult patients with PCD, 40 patients with CF with at least one F508del allele before and 3 months after initiation of ETI and 15 age-matched health...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD061751 | Pride
Sputum Cystic fibrosis Cf Primary ciliary dyskinesia Mucus Elexacaftor/tezacaftor/ivacaftor Hf-x Pcd Dda Airway inflammation 
Proteomics,MultiomicsSystematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H; Carr SA, Regev A, Amit I, Hacohen N. Cell, 2011, 147(4) 853-867. doi: 10...
2013-12-10 | MSV000078507 | MassIVE
ProteomicsTime-Dependent Proteome Study: Human-in-mouse xenograft breast cancer tumor samples (0, 5, 30, 60 min)
The objective of the Time-Dependent Proteome Study was to evaluate changes in the proteome and phosphoproteome when there is a delay in freezing tissues following sample (tumor) excision. The biospecimens used are from human-in-mouse breast cancer tumor samples.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-08-30 | MSV000084260 | MassIVE
ProteomicsTime-Dependent Proteome Study: Human ovarian cancer tumor samples (0, 5, 30, 60 min)

The objective of the Time-Dependent Proteome Study, was to evaluate changes in the proteome and phosphoproteome when there is a delay in freezing tissues following sample (tumor) excision. The biospecimens used are from patient-derived ovarian cancer tumors.

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-05 | MSV000083107 | MassIVE
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